| Acute renal failure in severely burned patients. | |
| | |
MedLine Citation:
|
PMID: 10208394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Acute renal failure (ARF) is a well known complication of severe burns and is an important factor leading to an increase in mortality. In order to analyze possible pathogenetic and prognostic factors associated with ARF in burned patients we reviewed in a retrospective study the files of 328 patients with burns > 10% body surface area (BSA), admitted to our burn unit between 01.01.94 and 01.05.98. We found 48 patients with acute renal failure corresponding with an incidence of 14.6%. Patients with ARF had a mean burned surface area of 48% (13-95) and an abbreviated burn severity index score (ABSI) of 9.8 (4-15). Thirty eight (79%) of these patients had an inhalation injury diagnosed. Renal insufficiency was divided in a late and an early form depending on its time of onset and we found 15 (31%) patients with ARF occurring within the first 5 days of the hospital stay and 33 (69%) patients with ARF developing >5 days following the thermal injury. The incidence of myoglobinuria and hypotension during the resuscitation phase was significantly higher in the group with early ARF, whereas patients with late ARF presented sepsis more frequently than patients with early occurring renal failure. Accordingly, potential nephrotoxic antibiotics were administered more often in patients with late ARF. Patients with ARF were treated by continuous arteriovenous hemofiltration (CAVH) for a mean period of 10.5 days (1-47) and CAVH was associated with a complication rate of 10%. Most of the complications were associated with the vascular access in the femoral artery. The mortality rate in patients with ARF was 85% and death was due to multiple organ failure in 83% of the cases. Only burned BSA and inhalation injury proved to be significantly correlated with the development of ARF, whereas age, third degree burn or electric injury were not significantly different between the two groups. Neither age, TBSA, day of onset of ARF nor duration of the renal replacement therapy proved to be significantly different comparing survivors with non-survivors, and thus predictive for the survival rate. |
| | |
Authors:
|
C Holm; F Hörbrand; G H von Donnersmarck; W Mühlbauer |
Related Documents
:
|
1572844 - Cultured epidermis: indiana university medical center's experience. 16365504 - What is the meaning of standard venous admixture formula results in septic patients? 11497154 - Elevation of troponin i in sepsis and septic shock. 3631764 - Leukopenia secondary to silver sulfadiazine: frequency, characteristics and clinical co... 20886004 - Flow cytometry and polymerase chain reaction-based analyses of minimal residual disease... 6452614 - Hypocomplementemia in reye syndrome: relationship to disease stage, circulating immune ... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Burns : journal of the International Society for Burn Injuries Volume: 25 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1999 Mar |
Date Detail:
|
Created Date: 1999-06-07 Completed Date: 1999-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 171-8 Citation Subset: IM |
Affiliation:
|
Department of Plastic and Reconstructive Surgery, Hand Surgery, Burn Center, Krankenhaus München-Bogenhausen, Academic Teaching Hospital, Technical University Munich, Germany. wmuehlbauer@t-online.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Burns / complications*, diagnosis, mortality Female Follow-Up Studies Hemofiltration Humans Incidence Kidney Failure, Acute / epidemiology, etiology*, therapy Male Middle Aged Prognosis Retrospective Studies Survival Rate Trauma Severity Indices |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prestorage leukocyte filtration may reduce leukocyte-derived bioactive substance accumulation in pat...
Next Document: A new in vitro model to study interaction between whole blood and biomaterials. Studies of platelet ...