Document Detail

Acute renal failure in the new millennium: time to consider combination therapy.
MedLine Citation:
PMID:  10651214     Owner:  NLM     Status:  MEDLINE    
Acute renal failure (ARF) occurs frequently and results in an unacceptably high morbidity and mortality. There is no currently accepted specific therapy that alters the course of ischemic ARF. Recent experimental advances and continued funding of ARF studies should allow rapid progress in the new millennium. This will require novel approaches to both basic and clinical evaluations. New experimental models and studies evaluating multiple therapies are needed. In addition, methods to identify ARF early in its course are likely to improve outcomes. Clinical studies should employ very specific definitions of ARF, outcomes evaluated, indications for renal replacement therapy, and severity of illness evaluation methods. Such studies and aggressive preventative measures will significantly improve the incidence and outcome of ARF in the 21st century.
K J Kelly; B A Molitoris
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  20     ISSN:  0270-9295     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-02     Completed Date:  2000-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-19     Citation Subset:  IM    
University of Cincinnati College of Medicine, OH, USA.
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MeSH Terms
Combined Modality Therapy / trends
Ischemia / physiopathology
Kidney Failure, Acute / mortality,  physiopathology*,  therapy*
Renal Dialysis
Renal Replacement Therapy / trends
Grant Support

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