| Acute renal failure in the new millennium: time to consider combination therapy. | |
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MedLine Citation:
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PMID: 10651214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute renal failure (ARF) occurs frequently and results in an unacceptably high morbidity and mortality. There is no currently accepted specific therapy that alters the course of ischemic ARF. Recent experimental advances and continued funding of ARF studies should allow rapid progress in the new millennium. This will require novel approaches to both basic and clinical evaluations. New experimental models and studies evaluating multiple therapies are needed. In addition, methods to identify ARF early in its course are likely to improve outcomes. Clinical studies should employ very specific definitions of ARF, outcomes evaluated, indications for renal replacement therapy, and severity of illness evaluation methods. Such studies and aggressive preventative measures will significantly improve the incidence and outcome of ARF in the 21st century. |
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Authors:
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K J Kelly; B A Molitoris |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 20 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-02 Completed Date: 2000-03-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4-19 Citation Subset: IM |
Affiliation:
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University of Cincinnati College of Medicine, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Combined Modality Therapy / trends Humans Ischemia / physiopathology Kidney Failure, Acute / mortality, physiopathology*, therapy* Renal Dialysis Renal Replacement Therapy / trends |
| Grant Support | |
ID/Acronym/Agency:
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DK-02364/DK/NIDDK NIH HHS; DK-41126/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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