Document Detail

Acute renal effects of angiotensin converting enzyme inhibition in microalbuminuric type 1 diabetic patients.
MedLine Citation:
PMID:  8111075     Owner:  NLM     Status:  MEDLINE    
The renal effects of intravenous injection of 10 mg enalapril were investigated in 16 normotensive microalbuminuric type 1 (insulin-dependent) diabetic patients. After enalapril the following changes were observed: fractional albumin clearance (theta Alb) decreased from 9.9 (3.0-23.8) to 8.2 (2.0-18.3) x 10(-6) (2 P < 0.01); filtration fraction (FF) decreased from 0.260 (0.225-0.312) to 0.253 (0.190-0.297) (2 P < 0.01); renal plasma flow (RPF) increased from 565 (411-690) to 623 (449-785) (2 P < 0.01); and glomerular filtration rate (GFR) remained stable at 149 (128-181) versus 150 (124-185) ml.min-1 (NS). These values were unchanged after placebo (n = 8), except for RFP which decreased from 606 (401-701) to 559 (381-677) ml.min-1 (2 P < 0.05) and GFR which was reduced from 148 (111-173) to 138 (111-167) (2 P < 0.05). A reduction in mean blood pressure from 94 (87-103) to 89 (79-101) mmHg (2 P < 0.05) was found in the enalapril group and a minor reduction in the placebo group from 97 (83-106) to 96 (81-104) mmHg (2 P < 0.05) was also noted. The relative changes in systolic blood pressure in the enalapril group correlated with changes in theta Alb (Spearman's r = 0.66, 2 P < 0.02) and FF (r = 0.53, 2 P < 0.05). Acute inhibition of angiotensin converting enzyme does not reduce the pathological hyperfiltration in these patients and a reduction in theta Alb and FF can not be dissociated from the reduction in blood pressure.
K W Hansen; M M Pedersen; J S Christiansen; C E Mogensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta diabetologica     Volume:  30     ISSN:  0940-5429     ISO Abbreviation:  Acta Diabetol     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-31     Completed Date:  1994-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Medical Department M (Diabetes and Endocrinology), Aarhus Kommunehospital, Denmark.
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MeSH Terms
Blood Glucose / drug effects
Blood Pressure / drug effects
Diabetes Mellitus, Type 1 / blood,  physiopathology*
Diabetic Nephropathies / blood,  physiopathology*
Diastole / drug effects
Enalapril / pharmacology*
Glomerular Filtration Rate / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects*
Middle Aged
Renal Circulation / drug effects*
Systole / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Blood Glucose; 75847-73-3/Enalapril

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