Document Detail

Acute renal dysfunction after cardiac surgery with cardiopulmonary bypass is associated with plasmatic IL6 increase.
MedLine Citation:
PMID:  19128984     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute renal dysfunction (ARD) is common after cardiac surgery with cardiopulmonary bypass (CPB). CPB results in a sudden systemic inflammatory response. Systemic and local pro-inflammatory cytokines synthesis has been linked with sub-clinical renal injury, especially tubular lesions. Therefore, we sought to assess the systemic synthesis pro-inflammatory cytokines and its association with perioperative ARD after cardiac surgery with CPB. METHODS: Sixty-two patients undergoing cardiac surgery with CPB were prospectively included. Four groups of patients were defined according to blood creatinine increase: no ARD (less than 25% increase), faint ARD (25-50% increase), moderate ARD (50-100% increase), severe ARD (more than 100% increase). RESULTS: Within the 48 post-operative hours was ARD observed as no dysfunction (41.9%), faint (32.2%), moderate (16.1%), severe (9.6%). One patient had to undergo a dialysis. Pre-operative characteristics were homogenous between the four groups excepted the left ventricle ejection fraction. ARD was associated with a low urinary output with high sodium excretion fraction. Significant increase of IL-6 level occurred when patients underwent a severe ARD despite no significant differences for the CRP and TNF-alpha concentrations. CONCLUSION: Severe acute renal dysfunction after cardiac surgery with CPB is associated with a significant increased IL-6 systemic production.
Gildas Gueret; Francois Lion; Nathalie Guriec; Josiane Arvieux; Annabelle Dovergne; Catherine Guennegan; Eric Bezon; Raoul Baron; Jean-Luc Carre; Charles Arvieux
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Publication Detail:
Type:  Journal Article     Date:  2009-01-06
Journal Detail:
Title:  Cytokine     Volume:  45     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-8     Citation Subset:  IM    
Anesthesiology and Critical Care Department, Centre Hospitalier Universitaire, 29609 Brest, France.
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MeSH Terms
Cardiac Surgical Procedures / adverse effects*
Cardiopulmonary Bypass / adverse effects*
Creatinine / blood
Interleukin-6 / blood*
Kidney Failure, Acute* / blood,  etiology
Middle Aged
Postoperative Complications / blood*
Urea / blood
Reg. No./Substance:
0/Interleukin-6; 57-13-6/Urea; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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