| Acute renal dysfunction after cardiac surgery with cardiopulmonary bypass is associated with plasmatic IL6 increase. | |
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MedLine Citation:
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PMID: 19128984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute renal dysfunction (ARD) is common after cardiac surgery with cardiopulmonary bypass (CPB). CPB results in a sudden systemic inflammatory response. Systemic and local pro-inflammatory cytokines synthesis has been linked with sub-clinical renal injury, especially tubular lesions. Therefore, we sought to assess the systemic synthesis pro-inflammatory cytokines and its association with perioperative ARD after cardiac surgery with CPB. METHODS: Sixty-two patients undergoing cardiac surgery with CPB were prospectively included. Four groups of patients were defined according to blood creatinine increase: no ARD (less than 25% increase), faint ARD (25-50% increase), moderate ARD (50-100% increase), severe ARD (more than 100% increase). RESULTS: Within the 48 post-operative hours was ARD observed as no dysfunction (41.9%), faint (32.2%), moderate (16.1%), severe (9.6%). One patient had to undergo a dialysis. Pre-operative characteristics were homogenous between the four groups excepted the left ventricle ejection fraction. ARD was associated with a low urinary output with high sodium excretion fraction. Significant increase of IL-6 level occurred when patients underwent a severe ARD despite no significant differences for the CRP and TNF-alpha concentrations. CONCLUSION: Severe acute renal dysfunction after cardiac surgery with CPB is associated with a significant increased IL-6 systemic production. |
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Authors:
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Gildas Gueret; Francois Lion; Nathalie Guriec; Josiane Arvieux; Annabelle Dovergne; Catherine Guennegan; Eric Bezon; Raoul Baron; Jean-Luc Carre; Charles Arvieux |
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Publication Detail:
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Type: Journal Article Date: 2009-01-06 |
Journal Detail:
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Title: Cytokine Volume: 45 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 92-8 Citation Subset: IM |
Affiliation:
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Anesthesiology and Critical Care Department, Centre Hospitalier Universitaire, 29609 Brest, France. gildas.gueret@chu-brest.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Surgical Procedures / adverse effects* Cardiopulmonary Bypass / adverse effects* Creatinine / blood Female Humans Interleukin-6 / blood* Kidney Failure, Acute* / blood, etiology Male Middle Aged Postoperative Complications / blood* Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 57-13-6/Urea; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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