| Acute refractory hyperkalaemia and fatal cardiac arrest related to administration of liposomal amphotericin B. | |
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MedLine Citation:
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PMID: 19011270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 36-year-old male with acute myeloid leukaemia was treated with liposomal amphotericin B for a breakthrough fungal infection with Absidia corymbifera during voriconazole and caspofungin therapy for invasive pulmonary aspergillosis. Four episodes of hyperkalaemia developed with a highly probable relation to infusion of liposomal amphotericin B, of which the last episode was characterised by severe, refractory hyperkalaemia and fatal cardiac arrest. The available literature on severe hyperkalaemia and cardiac arrest during administration of both conventional and liposomal amphotericin B is reviewed here and revealed only four similar cases. The most likely mechanism of toxicity is the release of potassium from a variety of mammal cells including erythrocytes and endothelial cells. Whether prevention of toxicity can be established by decreasing the infusion rate is unclear but conceivable. |
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Authors:
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O A Groot; R J Trof; A R Girbes; N L Swart; A Beishuizen |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 66 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-01-13 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 433-7 Citation Subset: IM |
Affiliation:
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Department of Intensive Care and Clinical Pharmacology, VU Medical Center, Amsterdam, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absidia
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isolation & purification Adult Amphotericin B / adverse effects*, therapeutic use Antifungal Agents / adverse effects*, therapeutic use Fatal Outcome Heart Arrest / chemically induced* Humans Hyperkalemia / chemically induced* Leukemia, Myeloid, Acute / drug therapy, microbiology Male Mucormycosis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 1397-89-3/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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