Document Detail


Acute re-feeding reverses food restriction-induced hypothalamic-pituitary-gonadal axis deficits.
MedLine Citation:
PMID:  11090441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Undernutrition has well-established effects on female reproduction. Here we describe the effects of food restriction on aspects of the hypothalamic-pituitary-gonadal (HPG) axis in the female musk shrew. We determined that acute re-feeding reverses deficits brought on by food restriction. Two days of food restriction led to an increase in proGnRH immunoreactive cells in the preoptic area relative to ad libitum-fed controls (AL). This increase was reversed by 90 min of ad libitum feeding in the re-fed females (RF). In addition, food-restricted (FR) females had significantly greater GnRH content in the median eminence than either the AL or RF females. After GnRH was administered, the majority of females in all food conditions ovulated, yet the FR females had significantly fewer corpora lutea than either the AL or RF animals. These data show that food restriction impairs HPG axis function in female musk shrews, and that some of these impairments can be rapidly reversed by acute re-feeding.
Authors:
J L Temple; E F Rissman
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of reproduction     Volume:  63     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-23     Completed Date:  2001-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1721-6     Citation Subset:  IM    
Affiliation:
Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22903, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Count
Corpus Luteum / metabolism
Eating / physiology*
Female
Food Deprivation / physiology*
Gonadotropin-Releasing Hormone / metabolism
Gonads / cytology,  physiology*
Hypothalamo-Hypophyseal System / cytology,  physiology*
Immunohistochemistry
Median Eminence / metabolism
Neurons / physiology
Ovulation / physiology
Preoptic Area / metabolism
Shrews / physiology*
Grant Support
ID/Acronym/Agency:
KO1 MH 01349/MH/NIMH NIH HHS; R01 NS 35429/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone

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