| Acute pyelonephritis in pregnancy: a prospective study of oral versus intravenous antibiotic therapy. | |
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MedLine Citation:
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PMID: 2193265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety pregnant women admitted to the high-risk pregnancy unit with a diagnosis of acute pyelonephritis were randomized to receive either oral (cephalexin 500 mg every 6 hours) or intravenous (IV) (cephalothin 1 g every 6 hours) antibiotic therapy. All patients were initially hydrated with 1 L of normal saline IV over 4 hours. Neither parenteral analgesics nor antiemetics were used. Bacteremia was noted in 13 (14.4%) of the 90 patients and mandated IV therapy. There was no difference between the oral and IV groups concerning predefined criteria for successful therapy (91.4 versus 92.9% successful therapy, respectively). No characteristic available at presentation predicted bacteremia or ultimate failure of therapy. Two patients (2.2%) experienced significant complications. These data suggest that in nonbacteremic patients, oral antibiotics are both safe and effective for the treatment of acute pyelonephritis in pregnancy. |
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Authors:
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J L Angel; W F O'Brien; M A Finan; W J Morales; M Lake; R A Knuppel |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 76 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-07-31 Completed Date: 1990-07-31 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 28-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of South Florida, College of Medicine, Tampa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Adult Anti-Bacterial Agents / administration & dosage* Escherichia coli / isolation & purification Female Humans Injections, Intravenous Length of Stay Pregnancy Pregnancy Complications, Infectious / drug therapy*, microbiology Prospective Studies Pyelonephritis / drug therapy*, microbiology Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 1990 Nov;76(5 Pt 1):891-2
[PMID:
2216244
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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