Document Detail


Acute pulmonary toxicity of a commercial fluorocarbon--lipid aerosol.
MedLine Citation:
PMID:  581077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The death of an adolescent after deliberate inhalation of the domestic fluorocarbon--lipid spray, PAM, triggered an investigation of the effects of this product on mammalian lung. Some of its constituents are known to destroy the lung-surfactant system, but death from its inhalation by earlier victims was usually attributed to the fluorocarbon's cardiac arrhythmogenic properties. In the present study, we applied methods and experimental models not previously used to study the effects of this aerosol material on the lung surfactant. We found morphological and functional acute disintegration of normal alveolar surfactant, leading to extensive alveolar collapse, with sustained and elevated surface tensions in vitro. This could result in fatal hypoxaemia at inspired concentrations of fluorocarbons insufficient to cause cardiac arrhythmias, and may explain at least partly the large number of deaths associated with inhalation of such product.
Authors:
D G Fagan; J B Forrest; G Enhörning; M Lamprey; J Guy
Related Documents :
581077 - Acute pulmonary toxicity of a commercial fluorocarbon--lipid aerosol.
7649917 - Artificial surfactant attenuates hyperoxic lung injury in primates. i. physiology and b...
22108527 - Dysglycemia induces abnormal circadian blood pressure variability.
1437337 - Lung mechanics and gas exchange in ventilated preterm infants during treatment of hyali...
3795307 - Pneumatic antishock garments (pasg): do they precipitate lower-extremity compartment sy...
16996957 - Biologically variable bypass reduces enzymuria after deep hypothermic circulatory arrest.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  1     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1977 May 
Date Detail:
Created Date:  1978-10-18     Completed Date:  1978-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-23     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aerosol Propellants / toxicity*
Aerosols / toxicity*
Airway Resistance / drug effects
Animals
Fluorocarbons / toxicity*
Lipids / toxicity*
Lung / drug effects*,  ultrastructure
Lung Compliance / drug effects
Pulmonary Surfactants*
Rabbits
Respiration / drug effects
Sheep
Chemical
Reg. No./Substance:
0/Aerosol Propellants; 0/Aerosols; 0/Fluorocarbons; 0/Lipids; 0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oxygen tension of the vaginal surface during sexual stimulation in the human.
Next Document:  Lipid composition of sputum from patients with asthma and patients with cystic fibrosis.