Document Detail

Acute pulmonary edema after diazepam-ketamine in a dog.
MedLine Citation:
PMID:  17565575     Owner:  NLM     Status:  MEDLINE    
An 8-year-old mixed-breed dog was anesthetized for colonoscopy. Moderate sedation was produced by premedication with glycopyrrolate, acepromazine, and hydromorphone, and anesthesia was induced by IV injection of diazepam and ketamine. Frothy, reddish-colored fluid flowed from the endotracheal tube immediately after endotracheal intubation but ceased after several minutes. Furosemide was injected IV. Anesthesia was maintained by sevoflurane in oxygen. Ventilation and arterial blood pressure were satisfactory, however, after oxygen was administered to maintain normal hemoglobin saturation. Radiography revealed changes consistent with a diagnosis of pulmonary edema. The following day, ventricular premature contractions developed and atrial dissociation, valvular regurgitation, and pulmonary hypertension were diagnosed on echocardiography. The proposed etiology is either profound transient hypotension and/or pulmonary hypertension induced by ketamine. The cardiac abnormalities that were present the following day suggest that myocardial dysfunction after induction of anesthesia was more severe than was apparent as assessed by routine physical examination and monitoring methods.
Joseph Boutureira; Cynthia M Trim; Karen K Cornell
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-06-12
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  34     ISSN:  1467-2987     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
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MeSH Terms
Adjuvants, Anesthesia / administration & dosage,  adverse effects*
Anesthesia / veterinary
Diagnosis, Differential
Diazepam / administration & dosage,  adverse effects*
Dog Diseases / chemically induced,  diagnosis*,  physiopathology
Dogs / physiology
Injections, Intravenous / veterinary
Ketamine / administration & dosage,  adverse effects*
Postoperative Complications / diagnosis,  veterinary
Pulmonary Edema / diagnosis,  veterinary*
Reg. No./Substance:
0/Adjuvants, Anesthesia; 439-14-5/Diazepam; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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