Document Detail

Acute psychosis leads to increased QT variability in patients suffering from schizophrenia.
MedLine Citation:
PMID:  17630259     Owner:  NLM     Status:  MEDLINE    
Patients with schizophrenia have been reported to experience sudden cardiac death 3 times more likely than individuals from the general population. One important factor related to an increased risk of cardiac arrhythmias and sudden death is the prolongation of the QTc interval. This study examined whether acute psychosis might influence the beat-to-beat variability of the QT interval, which reflects effectively cardiac repolarization lability. High resolution electrocardiographic recordings were performed in 25 unmedicated patients suffering from acute schizophrenia and matched controls. From these, parameters of beat-to-beat heart rate and QT variability measures such as approximate entropy and QT variability index (QTvi) were calculated. Measures were correlated with the scale for the assessment of positive symptoms (SAPS) and negative symptoms (SANS). QTvi was significantly higher in patients with schizophrenia compared to controls. While QTvi correlated with the degree of delusions and hallucinations, no correlation with electrolyte concentrations was found. Approximate entropy of heart rate was decreased indicating reduced complexity and decreased vagal tone. In conclusion, increased QT variability in patients with schizophrenia indicates abnormal cardiac repolarization lability, which can result in serious cardiac arrhythmias. The correlation of positive symptoms with QT variability might indicate high sympathetic cardiac activity in these patients, which might be associated with increased cardiovascular mortality.
Karl-Jürgen Bär; Mandy Koschke; Michael Karl Boettger; Sandy Berger; Alexander Kabisch; Heinrich Sauer; Andreas Voss; Vikram K Yeragani
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-16
Journal Detail:
Title:  Schizophrenia research     Volume:  95     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-10-24     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
Department of Psychiatry, Friedrich-Schiller-University Jena, Philosophenweg 3, 07743 Jena, Germany.
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MeSH Terms
Acute Disease
Autonomic Nervous System Diseases / diagnosis,  epidemiology
Death, Sudden, Cardiac / epidemiology,  etiology
Electroencephalography / methods,  statistics & numerical data*
Heart / innervation,  physiopathology
Heart Function Tests
Heart Rate / physiology
Long QT Syndrome / diagnosis*,  epidemiology,  physiopathology*
Psychiatric Status Rating Scales / statistics & numerical data
Schizophrenia / diagnosis*,  epidemiology,  physiopathology*
Schizophrenic Psychology
Vagus Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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