Document Detail

Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans.
MedLine Citation:
PMID:  10871712     Owner:  NLM     Status:  MEDLINE    
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") releases serotonin and dopamine. The role for dopamine in mediating the effects of MDMA has not yet been examined in humans. We investigated the effect of pretreatment with the dopamine D(2) antagonist haloperidol (1.4 mg i.v.) on psychological and physiological responses to MDMA (1.5 mg/kg p.o.) in 14 healthy volunteers using a double-blind placebo-controlled within-subject design. Subjective peak effects were rated using standardised scales. The physiological effects measured were blood pressure, heart rate and body temperature. Side effects were assessed during the session, and after 1 and 3 days. Haloperidol attenuated MDMA-induced positive and mania-like mood but had no reducing effect on other subjective changes or on cardiovascular effects. Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine.
M E Liechti; F X Vollenweider
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  10     ISSN:  0924-977X     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  289-95     Citation Subset:  IM    
University Hospital of Psychiatry Zurich, Research Unit, P.O. Box 68, CH-8029, Zurich, Switzerland.
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MeSH Terms
Affect / drug effects
Antipsychotic Agents / adverse effects,  pharmacology*,  therapeutic use
Anxiety / chemically induced,  prevention & control
Blood Pressure / drug effects
Body Temperature / drug effects
Consciousness / drug effects*
Dopamine / metabolism
Double-Blind Method
Drug Interactions
Hallucinogens / adverse effects,  pharmacology*
Haloperidol / adverse effects,  pharmacology*,  therapeutic use
Heart Rate / drug effects
Interviews as Topic
N-Methyl-3,4-methylenedioxyamphetamine / adverse effects,  pharmacology*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Hallucinogens; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 52-86-8/Haloperidol

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