| Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans. | |
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MedLine Citation:
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PMID: 10871712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") releases serotonin and dopamine. The role for dopamine in mediating the effects of MDMA has not yet been examined in humans. We investigated the effect of pretreatment with the dopamine D(2) antagonist haloperidol (1.4 mg i.v.) on psychological and physiological responses to MDMA (1.5 mg/kg p.o.) in 14 healthy volunteers using a double-blind placebo-controlled within-subject design. Subjective peak effects were rated using standardised scales. The physiological effects measured were blood pressure, heart rate and body temperature. Side effects were assessed during the session, and after 1 and 3 days. Haloperidol attenuated MDMA-induced positive and mania-like mood but had no reducing effect on other subjective changes or on cardiovascular effects. Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine. |
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Authors:
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M E Liechti; F X Vollenweider |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 10 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-09-14 Completed Date: 2000-09-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 289-95 Citation Subset: IM |
Affiliation:
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University Hospital of Psychiatry Zurich, Research Unit, P.O. Box 68, CH-8029, Zurich, Switzerland. mliechti@bli.unizh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / drug effects Antipsychotic Agents / adverse effects, pharmacology*, therapeutic use Anxiety / chemically induced, prevention & control Blood Pressure / drug effects Body Temperature / drug effects Consciousness / drug effects* Dopamine / metabolism Double-Blind Method Drug Interactions Hallucinogens / adverse effects, pharmacology* Haloperidol / adverse effects, pharmacology*, therapeutic use Heart Rate / drug effects Humans Interviews as Topic N-Methyl-3,4-methylenedioxyamphetamine / adverse effects, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Hallucinogens; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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