| Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C. | |
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MedLine Citation:
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PMID: 11834506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effect of fibroblast growth factor (FGF)-2 on myocardial resistance to injury when administered after the onset of ischemia, in vivo and ex vivo, and the role of FGF-2 receptors and protein kinase C (PKC). FGF-2 was injected into the left ventricle of rats undergoing permanent surgical coronary occlusion leading to myocardial infarction (MI). After 24 h, FGF-2-treated hearts displayed significantly reduced injury, determined by histological staining and troponin T release, and improved developed pressure compared with untreated controls. An FGF-2 mutant with diminished affinity for the tyrosine kinase FGF-2 receptor 1 (FGFR1) was not cardioprotective. FGF-2-treated hearts retained improved function and decreased damage at 6 wk after MI. In the ex vivo heart, FGF-2 administration during reperfusion after 30-min ischemia improved functional recovery and increased relative levels of PKC subtypes alpha, epsilon, and zeta in the particulate fraction, in a chelerythrine-preventable mode; it also decreased loss of energy metabolites. We conclude that intramyocardial FGF-2 administration shortly after the onset of ischemia confers protection from acute and chronic cardiac dysfunction and damage; FGF-2 delivered during reperfusion protects from ischemia-reperfusion injury; and protection by FGF-2 requires intact binding to FGFR1 and is likely mediated by PKC. |
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Authors:
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Zhi-Sheng Jiang; Raymond R Padua; Haisong Ju; Bradley W Doble; Yan Jin; Jianming Hao; Peter A Cattini; Ian M C Dixon; Elissavet Kardami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 282 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-04-03 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1071-80 Citation Subset: IM |
Affiliation:
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Department of Human Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R2H 2A6. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Diastole / drug effects Fibroblast Growth Factor 2 / administration & dosage, pharmacology* Heart Ventricles Injections Male Myocardial Contraction / drug effects Myocardial Infarction / physiopathology, prevention & control* Myocardial Ischemia / physiopathology, prevention & control* Myocardial Reperfusion Injury / prevention & control Protein Kinase C / metabolism* Rats Rats, Sprague-Dawley Receptor Protein-Tyrosine Kinases / physiology* Receptor, Fibroblast Growth Factor, Type 1 Receptor, Fibroblast Growth Factor, Type 2 Receptors, Fibroblast Growth Factor / physiology* Time Factors Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Receptors, Fibroblast Growth Factor; 0/Troponin T; 103107-01-3/Fibroblast Growth Factor 2; EC 2.7.10.1/Fgfr1 protein, rat; EC 2.7.10.1/Fgfr2 protein, rat; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 1; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 2; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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