Document Detail

Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C.
MedLine Citation:
PMID:  11834506     Owner:  NLM     Status:  MEDLINE    
We examined the effect of fibroblast growth factor (FGF)-2 on myocardial resistance to injury when administered after the onset of ischemia, in vivo and ex vivo, and the role of FGF-2 receptors and protein kinase C (PKC). FGF-2 was injected into the left ventricle of rats undergoing permanent surgical coronary occlusion leading to myocardial infarction (MI). After 24 h, FGF-2-treated hearts displayed significantly reduced injury, determined by histological staining and troponin T release, and improved developed pressure compared with untreated controls. An FGF-2 mutant with diminished affinity for the tyrosine kinase FGF-2 receptor 1 (FGFR1) was not cardioprotective. FGF-2-treated hearts retained improved function and decreased damage at 6 wk after MI. In the ex vivo heart, FGF-2 administration during reperfusion after 30-min ischemia improved functional recovery and increased relative levels of PKC subtypes alpha, epsilon, and zeta in the particulate fraction, in a chelerythrine-preventable mode; it also decreased loss of energy metabolites. We conclude that intramyocardial FGF-2 administration shortly after the onset of ischemia confers protection from acute and chronic cardiac dysfunction and damage; FGF-2 delivered during reperfusion protects from ischemia-reperfusion injury; and protection by FGF-2 requires intact binding to FGFR1 and is likely mediated by PKC.
Zhi-Sheng Jiang; Raymond R Padua; Haisong Ju; Bradley W Doble; Yan Jin; Jianming Hao; Peter A Cattini; Ian M C Dixon; Elissavet Kardami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-03     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1071-80     Citation Subset:  IM    
Department of Human Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada R2H 2A6.
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MeSH Terms
Biological Markers / blood
Diastole / drug effects
Fibroblast Growth Factor 2 / administration & dosage,  pharmacology*
Heart Ventricles
Myocardial Contraction / drug effects
Myocardial Infarction / physiopathology,  prevention & control*
Myocardial Ischemia / physiopathology,  prevention & control*
Myocardial Reperfusion Injury / prevention & control
Protein Kinase C / metabolism*
Rats, Sprague-Dawley
Receptor Protein-Tyrosine Kinases / physiology*
Receptor, Fibroblast Growth Factor, Type 1
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor / physiology*
Time Factors
Troponin T / blood
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Fibroblast Growth Factor; 0/Troponin T; 103107-01-3/Fibroblast Growth Factor 2; EC protein, rat; EC protein, rat; EC Protein-Tyrosine Kinases; EC, Fibroblast Growth Factor, Type 1; EC, Fibroblast Growth Factor, Type 2; EC Kinase C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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