Document Detail

Acute propranolol administration effectively decreases portal pressure in patients with TIPS dysfunction. Transjugular intrahepatic portosystemic shunt.
MedLine Citation:
PMID:  12477774     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Up to 60% of patients treated with transjugular intrahepatic portosystemic shunt (TIPS) require angioplasty or restenting during the first year of follow up because of TIPS dysfunction (stenosis of the intrahepatic shunt increasing the portal pressure gradient above the 12 mm Hg threshold). We hypothesised that in patients with TIPS stenosis, propranolol administration, by decreasing portal inflow, would markedly decrease portal pressure.
PATIENTS AND METHODS: Eighteen patients with TIPS dysfunction were investigated by measuring portal pressure gradient before and after acute propranolol administration (0.2 mg/kg intravenously; n=18).
RESULTS: Propranolol markedly reduced the portal pressure gradient (from 16.6 (3.5) to 11.9 (4.8) mm Hg; p<0.0001), cardiac index (-26 (7)%), and heart rate (-18 (7)%) (p<0.0001). Portal pressure gradient decreased to less than 12 mm Hg in nine patients, more frequently in those with moderate dysfunction (portal pressure gradient 16 mm Hg) than in patients with severe dysfunction (portal pressure gradient >16 mm Hg) (8/10 v 1/8; p=0.015).
CONCLUSIONS: Propranolol therapy may delay the increase in portal pressure and reduce the need for reintervention in patients with TIPS dysfunction.
L Bellis; E Moitinho; J G Abraldes; M Graupera; J C García-Pagán; J Rodés; J Bosch
Related Documents :
1654254 - Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to int...
3070104 - Mechanisms of blood pressure oscillation caused by central nervous system ischemic resp...
12736184 - Effect of portal hypertension on splenic blood flow, intrasplenic extravasation and sys...
3196594 - A protamine filter for extracorporeal blood heparin removal.
19947094 - Skin assessment of patients at risk of pressure ulcers.
3741354 - Incoordinate contraction and relaxation in d-transposition of the great arteries with i...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  52     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-12     Completed Date:  2003-02-20     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  AIM; IM    
Hepatic Hemodynamic Laboratory, Liver Unit, IMD, Hospital Clínic, Institut d'Investigacions Biomédiques August Pi I Sunyer, University of Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / therapeutic use*
Cardiac Output / drug effects
Heart Rate / drug effects
Hypertension, Portal / drug therapy,  surgery*
Middle Aged
Portal Pressure / drug effects
Portasystemic Shunt, Transjugular Intrahepatic*
Propranolol / therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of smoking on histological liver lesions in chronic hepatitis C.
Next Document:  MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is corre...