Document Detail

Acute propafenone toxicity after two exposures at standard dosing.
MedLine Citation:
PMID:  20548984     Owner:  NLM     Status:  MEDLINE    
A 72-year-old woman presented with a decreased level of consciousness and hypotension. The initial electrocardiogram demonstrated atrial fibrillation with a wide QRS complex. Her medical history revealed that she had just been started on propafenone. A diagnosis of propafenone toxicity was made and sodium bicarbonate was administered. A rare phenomenon in which toxicity occurred at therapeutic dosing is reported. Acute propafenone toxicity manifests in a wide range of organ systems; in particular, cardiovascular compromise in the form of hypotension, bradycardia and QRS widening can occur. Sodium bicarbonate therapy is advocated to directly counteract the toxic effects of propafenone. In the case described, this treatment resulted in rapid normalization of the QRS duration and stabilization of the hemodynamic profile.
Adam Yeung; David Shanks; Harjinder Parwana; Kenneth Gin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  26     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:    2010 Jun-Jul
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-07-15     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  209-10     Citation Subset:  IM    
Department of Internal Medicine, University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Acute Disease
Anti-Arrhythmia Agents / administration & dosage,  adverse effects*
Atrial Fibrillation / drug therapy*,  physiopathology
Consciousness Disorders / chemically induced*,  drug therapy,  physiopathology
Dose-Response Relationship, Drug
Electrocardiography / drug effects
Hypotension / chemically induced*,  drug therapy,  physiopathology
Infusions, Intravenous
Propafenone / administration & dosage,  adverse effects*
Sodium Bicarbonate / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 144-55-8/Sodium Bicarbonate; 54063-53-5/Propafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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