| Acute propafenone toxicity after two exposures at standard dosing. | |
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MedLine Citation:
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PMID: 20548984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 72-year-old woman presented with a decreased level of consciousness and hypotension. The initial electrocardiogram demonstrated atrial fibrillation with a wide QRS complex. Her medical history revealed that she had just been started on propafenone. A diagnosis of propafenone toxicity was made and sodium bicarbonate was administered. A rare phenomenon in which toxicity occurred at therapeutic dosing is reported. Acute propafenone toxicity manifests in a wide range of organ systems; in particular, cardiovascular compromise in the form of hypotension, bradycardia and QRS widening can occur. Sodium bicarbonate therapy is advocated to directly counteract the toxic effects of propafenone. In the case described, this treatment resulted in rapid normalization of the QRS duration and stabilization of the hemodynamic profile. |
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Authors:
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Adam Yeung; David Shanks; Harjinder Parwana; Kenneth Gin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 26 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-07-15 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: 209-10 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of British Columbia, Vancouver, BC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Anti-Arrhythmia Agents / administration & dosage, adverse effects* Atrial Fibrillation / drug therapy*, physiopathology Consciousness Disorders / chemically induced*, drug therapy, physiopathology Dose-Response Relationship, Drug Electrocardiography / drug effects Female Humans Hypotension / chemically induced*, drug therapy, physiopathology Infusions, Intravenous Propafenone / administration & dosage, adverse effects* Sodium Bicarbonate / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 144-55-8/Sodium Bicarbonate; 54063-53-5/Propafenone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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