| Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts. | |
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MedLine Citation:
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PMID: 19061780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 32-year-old pregnant woman in the 13th gestational week was brought to Severance Hospital with gum bleeding and easy bruising. Initial laboratory results revealed anemia and thrombocytopenia. In a peripheral blood smear, 81% of leukocytes were large, abnormal promyelocytes. Bone marrow aspiration showed a hypercellular marrow with packed leukemic promyelocytes, and chromosome study revealed a karyotype of 46,XX,t(15;17)(q22;q21)[10]/46,XX[10]. In addition, variant fusion transcripts of PML/RARA were detected in the marrow specimen. The patient was diagnosed with acute promyelocytic leukemia (APL) and was treated with all-trans retinoic acid (ATRA) and idarubicin. One month from the patient's initial diagnosis a follow-up bone marrow examination was performed, revealing complete remission (CR). We know of no previous reports of APL during pregnancy associated with variant PML/RARA fusion transcripts. Here, we describe a novel case of APL in a pregnant woman with a t(15;17) translocation and variant fusion transcripts. |
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Authors:
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Tae Sung Park; Seung Tae Lee; Jin Seok Kim; Jaewoo Song; Kyung-A Lee; Sue Jung Kim; Yoon-Mi Seok; Hyeon-Ji Lee; Jeong-Hyun Han; Jong-Kee Kim; Eun Yup Lee; Jong Rak Choi |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 188 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 48-51 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents / therapeutic use Bone Marrow / pathology Female Humans Idarubicin / therapeutic use In Situ Hybridization, Fluorescence Karyotyping Korea Leukemia, Promyelocytic, Acute / diagnosis, drug therapy, genetics*, pathology Nuclear Proteins / genetics* Oncogene Proteins, Fusion / genetics* Pregnancy Pregnancy Complications, Neoplastic / diagnosis, drug therapy, genetics*, pathology Receptors, Retinoic Acid / genetics* Reverse Transcriptase Polymerase Chain Reaction Transcription Factors / genetics* Translocation, Genetic* Tretinoin / therapeutic use Tumor Suppressor Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Nuclear Proteins; 0/Oncogene Proteins, Fusion; 0/Receptors, Retinoic Acid; 0/Transcription Factors; 0/Tumor Suppressor Proteins; 0/retinoic acid receptor alpha; 143220-95-5/PML protein, human; 302-79-4/Tretinoin; 58957-92-9/Idarubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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