| Acute promyelocytic leukaemia: novel insights into the mechanisms of cure. | |
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MedLine Citation:
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PMID: 20966922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fusion oncogene, promyelocytic leukaemia (PML)-retinoic acid receptor-α (RARA), initiates acute promyelocytic leukaemia (APL) through both a block to differentiation and increased self-renewal of leukaemic progenitor cells. The current standard of care is retinoic acid (RA) and chemotherapy, but arsenic trioxide also cures many patients with APL, and an RA plus arsenic trioxide combination cures most patients. This Review discusses the recent evidence that reveals surprising new insights into how RA and arsenic trioxide cure this leukaemia, by targeting PML-RARα for degradation. Drug-triggered oncoprotein degradation may be a strategy that is applicable to many cancers. |
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Authors:
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Hugues de Thé; Zhu Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-22 |
Journal Detail:
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Title: Nature reviews. Cancer Volume: 10 ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: England |
Other Details:
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Languages: eng Pagination: 775-83 Citation Subset: IM |
Affiliation:
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Institut National de Santé et de Recherche Médicale, Centre National de Recherche Scientifique, Institut Universitaire d'Hématologie, Université Paris-Diderot UMR 944/7212, Equipe labellisée par Ligue contre Cancer, Service de Biochimie, Hôpital St. Louis, 2 avenue C. Vellefaux, 75475 Paris, CEDEX 10, France. dethe@univ-parisdiderot.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation Humans Leukemia, Promyelocytic, Acute / drug therapy*, pathology Models, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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