| Acute profound thrombocytopenia after treatment with tirofiban and off-pump coronary artery bypass grafting. | |
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MedLine Citation:
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PMID: 19161801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The glycoprotein IIb/IIIa (GP IIb/IIIa) receptor antagonists prevent platelet aggregation and thrombus formation, improving outcomes of patients with acute coronary syndrome. Therapy with these agents may lead to bleeding complications and thrombocytopenia, challenging the perioperative management of patients undergoing coronary surgery. We report the successful management of an acute profound thrombocytopenia after urgent off-pump coronary surgery in a patient treated with tirofiban for unstable angina and acute coronary syndrome. |
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Authors:
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Andres Beiras-Fernandez; Anke Kowert; Pascale Jiru; Marion Weis; Michael Spannagl; Bruno Reichart; Michael Schmoeckel |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 87 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-02-11 Revised Date: 2009-08-24 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 629-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany. andres.beiras@med.uni-muenchen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis,
drug therapy,
surgery Acute Disease Angina, Unstable / diagnosis, drug therapy, surgery Coronary Angiography Coronary Artery Bypass, Off-Pump / adverse effects, methods* Follow-Up Studies Heparin / adverse effects, therapeutic use Humans Infusions, Intravenous Male Middle Aged Platelet Aggregation Inhibitors / adverse effects, therapeutic use Platelet Count Platelet Transfusion / methods* Postoperative Complications / prevention & control Preoperative Care / methods Risk Assessment Severity of Illness Index Thrombocytopenia / chemically induced*, diagnosis, therapy* Thrombosis / prevention & control* Treatment Outcome Tyrosine / adverse effects, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 144494-65-5/tirofiban; 55520-40-6/Tyrosine; 9005-49-6/Heparin |
| Comments/Corrections | |
Comment In:
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Ann Thorac Surg. 2009 Sep;88(3):1048; author reply 1048
[PMID:
19699965
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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