Document Detail

Acute poststreptococcal glomerulonephritis associated with thrombotic microangiopathy in an adult.
MedLine Citation:
PMID:  10968697     Owner:  NLM     Status:  MEDLINE    
The simultaneous occurrence of acute poststreptococcal glomerulonephritis and thrombotic microangiopathy is rare. A 47-year-old woman was admitted with acute renal failure, hematuria, edematous nephrotic syndrome and severe hypertension. This acute nephritic syndrome occurred two weeks after left leg erysipelas. The patient also had signs of intravascular hemolysis, low serum levels of C3 and C4 and elevated antistreptolysin-O titer. Kidney biopsy confirmed postinfectious glomerulonephritis with diffuse hypercellularity and humps, and simultaneous subendothelial hyalin deposits and fibrinoid arteriolar thrombi. The patient received four antihypertensive drugs, acetylsalicyclic acid and plasma infusions. Renal function improved, hypertension was controlled and serum levels of C3 and C4 complement components returned to normal within three months. This case illustrates the occurrence of thrombotic microangiopathy in association with acute poststreptococcal glomerulonephritis. This simultaneous appearance supports a role of neuraminidase in this disease.
C Duvic; J Desramé; M Hérody; G Nédélec
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  54     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2000-12-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Clinique de Néphrologie et Unité d'Hémodialyse, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris, France.
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MeSH Terms
Acute Disease
Glomerulonephritis / complications,  etiology*,  pathology
Hemolytic-Uremic Syndrome / complications*
Kidney Glomerulus / pathology
Middle Aged
Streptococcal Infections / complications*
Thrombosis / complications*

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