| Acute portal hemodynamics and cytokine changesfollowing selective transarterial chemoembolization in patients with cirrhosis and hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 12960926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Altered portal hemodynamics and inflammation may occur following transcatheter arterial chemoembolization (TACE), but early biological and portal perfusion changes are not well characterized when this procedure is performed selectively. MATERIAL/METHODS: We studied variations in portal flow velocity (PFV) using Doppler ultrasonography, as well as serum TNFa, vCAM-1, and E-Selectin at 2 and 24 hours after supraselective TACE in 15 consecutive patients with cirrhosis and hepatocellular carcinoma. RESULTS: Variations in PFV occurred both in the embolized and non-embolized liver lobe. PFV increased significantly at 2 hours in the right and left portal vein. At 24 hours, right PFV remained elevated. Serum TNFa increased significantly at 2 hours, but VCAM-1 and E-Selectin levels remained unchanged. Changes in right and left PFV showed a positive correlation (r=0.9, p<0.001). No correlation could be observed between biological and Doppler changes in portal veins. CONCLUSIONS: In patients with cirrhosis and hepatocellular carcinoma, PFV increased in both liver lobes 2 hours after supraselective TACE, in association with high serum TNFa. Diffuse changes in PFV after TACE suggests that mechanisms involved in the regulation of portal and hepatic arterial hemodynamics are present in patients with cirrhosis. A major role for TNFa in acute portal flow velocity variations is unlikely in this situation. |
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Authors:
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Laurent Spahr; Christoph Becker; Jérôme Pugin; Pietro E Majno; Antonine Hadengue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 9 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-08 Completed Date: 2004-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR383-8 Citation Subset: IM |
Affiliation:
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Gastroenterology and Hepatology, University Hospital, Geneva, Switzerland. Laurent.Spahr@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alanine Transaminase / blood Aspartate Aminotransferases / blood Blood Flow Velocity Body Temperature / physiology Carcinoma, Hepatocellular / blood, blood supply*, therapy, ultrasonography Chemoembolization, Therapeutic* E-Selectin / blood* Female Humans Liver Cirrhosis / blood, physiopathology*, therapy Liver Neoplasms / blood, blood supply*, therapy, ultrasonography Male Middle Aged Portal Pressure / physiology Portal Vein / physiology, ultrasonography Tumor Necrosis Factor-alpha / metabolism* Ultrasonography, Doppler, Duplex Vascular Cell Adhesion Molecule-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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