Document Detail

Acute plasma volume expansion: effect on metabolism during submaximal exercise.
MedLine Citation:
PMID:  10484596     Owner:  NLM     Status:  MEDLINE    
To examine the effect of acute plasma volume expansion (PVE) on substrate selection during exercise, seven untrained men cycled for 40 min at 72 +/- 2% peak oxygen uptake (VO(2 peak)) on two occasions. On one occasion, subjects had their plasma volume expanded by 12 +/- 2% via an intravenous infusion of the plasma substitute Haemaccel, whereas on the other occasion no such infusion took place. Muscle samples were obtained before and immediately after exercise. In addition, heart rate and pulmonary gas and venous blood samples were obtained throughout exercise. No differences in oxygen uptake or heart rate during exercise were observed between trials, whereas respiratory exchange ratio, blood glucose, and lactate were unaffected by PVE. Muscle glycogen and lactate concentrations were not different either before or after exercise. In addition, there was no difference in total carbohydrate oxidation between trials (control: 108 +/- 2 g; PVE group: 105 +/- 2 g). Plasma catecholamine levels were not affected by PVE. These data indicate that substrate metabolism during submaximal exercise in untrained men is unaltered by acute hypervolemia.
M J Watt; M A Febbraio; A P Garnham; M Hargreaves
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1202-6     Citation Subset:  IM; S    
School of Health Sciences, Deakin University, Burwood, Victoria 3125, Australia.
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MeSH Terms
Carbohydrate Metabolism
Carbon Dioxide / blood
Exercise / physiology*
Glycogen / blood,  metabolism
Lactic Acid / blood,  metabolism
Metabolism / physiology
Muscle, Skeletal / drug effects,  metabolism,  physiology
Oxygen Consumption / drug effects,  physiology
Plasma Substitutes / pharmacology*
Plasma Volume / physiology*
Reg. No./Substance:
0/Plasma Substitutes; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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