Document Detail


Acute plasma volume expansion alters cardiovascular but not thermal function during moderate intensity prolonged exercise.
MedLine Citation:
PMID:  10721816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the hypothesis that the increase in plasma volume (PV) that typically occurs with training results in improved cardiovascular and thermal regulation during prolonged exercise, eight untrained males (V(O2)peak = 3.52 +/- 0.12 L x min(-1)) performed 90 min of cycle ergometry at 62% V(O2)peak before and after acute PV expansion. Subjects were infused with a PV-expanding solution (dextran (6%) or Pentaspan (10%)) equivalent to 6.7 mL x kg(-1) body mass (PVX) or acted as their own control (CON) in a randomized order. PVX resulted in a calculated 15.8% increase in resting PV, which relative to CON, was maintained throughout the exercise (P < 0.05). During PVX, heart rate was lower (P < 0.05) and stroke volume and cardiac output were higher (P < 0.05) during the exercise. Mean arterial pressure and total peripheral resistance, although altered by exercise (P < 0.05), were not different between the two conditions. Core temperature, which was progressively increased by the exercise (P < 0.01), was not affected by PVX. A similar decrease in body weight was observed between the conditions as a result of the exercise (P < 0.01). These results indicate that acute PVX alters cardiovascular performance without affecting the thermoregulatory response to prolonged cycle exercise.
Authors:
B D Roy; H J Green; S M Grant; M A Tarnopolsky
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  78     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-11     Completed Date:  2000-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, University of Waterloo, ON, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Temperature
Body Temperature Regulation*
Cardiac Output
Exercise*
Heart Rate
Hemodynamics*
Humans
Male
Oxygen Consumption
Plasma Volume*
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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