Document Detail


Acute phase responses and cytokine secretion in chronic fatigue syndrome.
MedLine Citation:
PMID:  10634215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study addresses the hypothesis that clinical manifestations of chronic fatigue syndrome (CFS) are due in part to abnormal production of or sensitivity to cytokines such as interleukin-1beta (IL-1beta) and IL-6 under basal conditions or in response to a particular physical stress: 15 min of exercise consisting of stepping up and down on a platform adjusted to the height of the patella. The study involved 10 CFS patients and 11 age-, sex-, and activity-matched controls: of these, 6 patients and 4 controls were tested in both the follicular and the luteal phases of the menstrual cycle, and the remainder were tested in only one phase, for a total of 31 experimental sessions. Prior to exercise, plasma concentrations of the acute phase reactant alpha2-macroglobulin were 29% higher in CFS patients (P < 0.008) compared to controls. Secretion of IL-6 was generally higher for CFS patients (approximately 38%), however, this difference was statistically significant only if all values over a 3-day period were analyzed by repeated-measures ANOVA (P = 0.035). IL-6 secretion correlated with plasma alpha2-macroglobulin in control subjects at rest (R = 0.767, P = 0.001). Immediately after exercise, the CFS patients reported greater ratings of perceived exertion (P=0.027) compared to the healthy control subjects. Ratings of perceived exertion correlated with IL-1beta secretion by cells from healthy control subjects (R = 0.603, P = 0.022), but not from CFS patients, and IL-1beta secretion was not different between groups. Exercise induced a slight (< 12%) but significant (P = 0.006) increase in IL-6 secretion, but the responses of the CFS patients were not different than controls. Furthermore, no significant exercise-induced changes in body temperature or plasma alpha2-macroglobulin were observed. These data indicate that under basal conditions, CFS is associated with increased IL-6 secretion which is manifested by chronically elevated plasma alpha2-macroglobulin concentrations. These modest differences suggest that cytokine dysregulation is not a singular or dominant factor in the pathogenesis of CFS.
Authors:
J G Cannon; J B Angel; R W Ball; L W Abad; L Fagioli; A L Komaroff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  19     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-01-28     Completed Date:  2000-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  414-21     Citation Subset:  IM    
Affiliation:
Department of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA. jgc2@psu.edu
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Reaction*
Body Temperature
Cytokines / secretion*
Exercise
Fatigue Syndrome, Chronic / immunology*
Female
Humans
Lipopolysaccharides / pharmacology
alpha-Macroglobulins / analysis
Grant Support
ID/Acronym/Agency:
AI32246/AI/NIAID NIH HHS; AI33414/AI/NIAID NIH HHS; M01 RR00054/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Lipopolysaccharides; 0/alpha-Macroglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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