Document Detail

Acute phase reactants in neonatal bacterial infection.
MedLine Citation:
PMID:  1722816     Owner:  NLM     Status:  MEDLINE    
The C-reactive protein (CRP) level was evaluated in 142 infants requiring investigation for suspected infection. After excluding two neonates because of incomplete data, there remained 140 neonates, of whom 16 had septicemia. Fifteen of 16 had increased CRP levels. The CRP value was not elevated in any baby (n = 5) who had positive blood cultures for Staphylococcus epidermidis, all of whom had an uneventful clinical course. The CRP level was elevated in all six babies with meconium-aspiration syndrome, but was normal in five infants whose viral cultures were positive. Ninety-nine percent of uninfected babies had normal CRP values. Overall, CRP was a valuable test for diagnostic confirmation of bacterial infection. Elevated CRP level was always accompanied by at least one abnormality in the other tests performed. Although the study was not intended to predict clinical onset of bacterial disease, our results suggest that the CRP level, because of a high negative predictive value, may be useful in ruling out bacterial infection.
M Pourcyrous; H S Bada; S B Korones; F F Barrett; W Jennings; T Lockey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  11     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  319-25     Citation Subset:  IM    
University of Tennessee, Memphis Department of Pediatrics, Obstetrics and Gynecology and Pathology.
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MeSH Terms
Acute-Phase Proteins / analysis
Bacteria / isolation & purification
Bacterial Infections / blood*,  diagnosis,  microbiology
C-Reactive Protein / analysis*
Cytomegalovirus / isolation & purification
Enterovirus / isolation & purification
Hematologic Tests
Immunoglobulin M / blood
Infant, Newborn / blood*,  immunology,  microbiology
Infant, Premature / blood,  immunology,  microbiology
Prospective Studies
Staphylococcus epidermidis / isolation & purification
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Immunoglobulin M; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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