Document Detail

Acute phase proteins in patients with abdominal aortic aneurysms.
MedLine Citation:
PMID:  2443505     Owner:  NLM     Status:  MEDLINE    
Both stenosis and aneurysmal dilatation are associated with atherosclerosis of the distal aorta. As part of an investigation into factors predisposing to aneurysmal dilatation we compared the levels of acute phase proteins in patients with stenosing and aneurysmal disease. Increased levels of acute phase proteins were found in patients with abdominal aortic aneurysms compared with patients with stenosing aortic disease. In 20 aneurysm patients the C-reactive protein was 56 +/- 10 mg/l, alpha 1-proteinase inhibitor 2.5 +/- 0.13 g/l and ceruloplasmin 0.41 +/- 0.01 g/l. In 20 patients with stenosing aortic disease the C-reactive protein was 28 +/- 8 mg/l, alpha 1-proteinase inhibitor 1.65 +/- 0.11 g/l and ceruloplasmin 0.35 +/- 0.03 g/l. These results argue for the participation of an inflammatory process in the aortic wall in the pathogenesis of all aneurysms.
J T Powell; B R Muller; R M Greenhalgh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  28     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:    1987 Sep-Oct
Date Detail:
Created Date:  1987-10-29     Completed Date:  1987-10-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  528-30     Citation Subset:  IM    
Department of Surgery, Charing Cross & Westminster Medical School, London, England.
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MeSH Terms
Acute-Phase Proteins / blood*
Aorta, Abdominal
Aortic Aneurysm / blood*,  surgery
Aortic Diseases / blood
C-Reactive Protein / analysis
Ceruloplasmin / analysis
Constriction, Pathologic / blood
alpha 1-Antitrypsin / analysis
Reg. No./Substance:
0/Acute-Phase Proteins; 0/alpha 1-Antitrypsin; 9007-41-4/C-Reactive Protein; EC

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