| Acute phase proteins in atherosclerosis (acute coronary syndrome). | |
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MedLine Citation:
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PMID: 18855639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigation of the mechanisms of atherosclerosis has determined that inflammation plays a central role in the development, progression, and outcome of acute coronary syndrome (ACS). C-reactive protein (CRP) plasma levels increase in patients with ACS. CPR is an important prognostic marker in ACS, following angioplasty, and in the long-term management of post-infarction patients. Although CRP will remain over time a useful marker, the role and implications of increased plasma concentrations of other acute phase proteins (APPs), such as alpha-1-antitrypsin (A1AT), alpha-1 glycoprotein (A1GP), haptoglobin (HG), ceruloplasmin (CP), and C3c and C4 complement fraction, in patients with ACS are still not completely defined. This short review summarizes the experimental and clinical evidence regarding the role, and the biological and clinical significance of these other APPs in ACS. |
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Authors:
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Michele Correale; Natale Daniele Brunetti; Luisa De Gennaro; Matteo Di Biase |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular & hematological agents in medicinal chemistry Volume: 6 ISSN: 1871-5257 ISO Abbreviation: - Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266881 Medline TA: Cardiovasc Hematol Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 272-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Foggia, viale L Pinto, 1. 71100 Foggia, Italy. opsfco@tin.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood,
drug therapy,
etiology* Acute-Phase Proteins / analysis*, physiology Atherosclerosis / blood, drug therapy, etiology* Collateral Circulation Complement C3 / analysis Complement C4 / analysis Coronary Circulation Haptoglobins / analysis Humans Inflammation / complications Orosomucoid / analysis alpha 1-Antitrypsin / blood |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Complement C3; 0/Complement C4; 0/Haptoglobins; 0/Orosomucoid; 0/alpha 1-Antitrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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