Document Detail

Acute phase proteins in atherosclerosis (acute coronary syndrome).
MedLine Citation:
PMID:  18855639     Owner:  NLM     Status:  MEDLINE    
Investigation of the mechanisms of atherosclerosis has determined that inflammation plays a central role in the development, progression, and outcome of acute coronary syndrome (ACS). C-reactive protein (CRP) plasma levels increase in patients with ACS. CPR is an important prognostic marker in ACS, following angioplasty, and in the long-term management of post-infarction patients. Although CRP will remain over time a useful marker, the role and implications of increased plasma concentrations of other acute phase proteins (APPs), such as alpha-1-antitrypsin (A1AT), alpha-1 glycoprotein (A1GP), haptoglobin (HG), ceruloplasmin (CP), and C3c and C4 complement fraction, in patients with ACS are still not completely defined. This short review summarizes the experimental and clinical evidence regarding the role, and the biological and clinical significance of these other APPs in ACS.
Michele Correale; Natale Daniele Brunetti; Luisa De Gennaro; Matteo Di Biase
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular & hematological agents in medicinal chemistry     Volume:  6     ISSN:  1871-5257     ISO Abbreviation:  -     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2008-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266881     Medline TA:  Cardiovasc Hematol Agents Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  272-7     Citation Subset:  IM    
Department of Cardiology, University of Foggia, viale L Pinto, 1. 71100 Foggia, Italy.
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MeSH Terms
Acute Coronary Syndrome / blood,  drug therapy,  etiology*
Acute-Phase Proteins / analysis*,  physiology
Atherosclerosis / blood,  drug therapy,  etiology*
Collateral Circulation
Complement C3 / analysis
Complement C4 / analysis
Coronary Circulation
Haptoglobins / analysis
Inflammation / complications
Orosomucoid / analysis
alpha 1-Antitrypsin / blood
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Complement C3; 0/Complement C4; 0/Haptoglobins; 0/Orosomucoid; 0/alpha 1-Antitrypsin

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