Document Detail


Acute phase proteins activation in subjects with coronary atherosclerosis and micro-vessel coronary circulation impairment.
MedLine Citation:
PMID:  18690412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate possible correlations between acute phase proteins (APPs) activation and coronary flow in subjects with coronary artery disease (CAD) undergoing coronary angiography. METHODS: Fifty-nine consecutive patients with CAD who underwent coronary angiography were enrolled in the study: blood samples were taken in order to evaluate plasmatic concentrations of C-reactive protein (CRP) and APPs such as alpha-1-anti-trypsin (A1AT), alpha-1-glyco-protein (A1GP) and haptoglobin (HG). Coronary flow on left anterior descending (LAD) was assessed with TIMI frame count (TFC). Patients with TIMI flow 0-1 were excluded from the study. RESULTS: Coronary atherosclerosis expressed in terms of number of coronary vessels with severe (>70%) lumen narrowing was related to serum concentrations of all considered APPs (A1GP: r 0.282, P < 0.05; A1AT: r 0.256, P 0.055; HG: r 0.335, P < 0.01). TFC on LAD was related to all considered APPs (A1GP: r 0.24, P 0.06; A1AT: r 0.28, P < 0.05; HG: r 0.43, P < 0.01; log CRP: r 0.57, P < 0.001); correlations remained significant even after correction for age, gender, risk factors, diagnosis and treatment. Among 12 patients who were previously treated with coronary angioplasty, those implanted with a drug eluting stent showed a significantly slower coronary flow on LAD (19.6 +/- 2.07 vs. 16.71 +/- 2.06, P < 0.05) if compared with those implanted with a bare metal stent. CONCLUSIONS: An increased inflammatory systemic activation featured by plasmatic concentrations of CRP and APPs might be associated with both coronary atherosclerosis and an impaired coronary micro-circulation.
Authors:
Natale Daniele Brunetti; Roberto Padalino; Luisa De Gennaro; Andrea Cuculo; Luigi Ziccardi; Pier Luigi Pellegrino; Matteo Di Biase
Publication Detail:
Type:  Journal Article     Date:  2008-08-09
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  28     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
Affiliation:
Cardiology Department, University of Foggia, Foggia, Italy. dr.natale.daniele.brunetti@hotmail.it
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis*
Aged
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Disease / blood*,  physiopathology*,  therapy
Coronary Circulation*
Drug-Eluting Stents
Female
Humans
Male
Microcirculation*
Middle Aged
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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