Document Detail


Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder: a review.
MedLine Citation:
PMID:  16102905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reviews the results of an acute phase trial and a five-year follow-up study of fluoxetine in adolescents with major depression and a substance use disorder (SUD). This study included a 12-week open label acute phase study of 13 comorbid adolescents, followed by comprehensive assessments conducted 1, 3, and 5 years after entry into an acute phase fluoxetine trial. The results of the acute phase study and of the 1, 3, and 5-year follow-up assessments have already been published in four papers. The current paper was designed to cover the results of the study across the entire 5-year time spectrum of the study, and to summarize the clinical results across that entire time period. The data from this pilot study suggest that the long-term (5-year) clinical course for the Alcohol Dependence, Cannabis Dependence, and academic functioning of comorbid adolescents following acute phase treatment with SSRIs is generally good. However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor.
Authors:
Jack R Cornelius; Duncan B Clark; Oscar G Bukstein; Boris Birmaher; Ihsan M Salloum; Sandra A Brown
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2005-08-15
Journal Detail:
Title:  Addictive behaviors     Volume:  30     ISSN:  0306-4603     ISO Abbreviation:  Addict Behav     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7603486     Medline TA:  Addict Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  1824-33     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PAARC Suite, Pittsburgh, PA 15213, USA. jcornel@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alcohol Drinking / psychology
Alcoholism / psychology
Antidepressive Agents, Second-Generation / adverse effects,  therapeutic use*
Combined Modality Therapy / methods
Depressive Disorder, Major / complications,  drug therapy*
Fluoxetine / adverse effects,  therapeutic use*
Follow-Up Studies
Humans
Marijuana Abuse / psychology
Pilot Projects
Psychotherapy / methods
Serotonin Uptake Inhibitors / adverse effects,  therapeutic use
Substance-Related Disorders / complications*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K02 AA00291/AA/NIAAA NIH HHS; K08 AA00280/AA/NIAAA NIH HHS; K24 AA00301/AA/NIAAA NIH HHS; P50 AA08746/AA/NIAAA NIH HHS; P50 DA05605/DA/NIDA NIH HHS; R01 AA013370/AA/NIAAA NIH HHS; R01 AA015173/AA/NIAAA NIH HHS; R01 AA11292/AA/NIAAA NIH HHS; R01 DA14635/DA/NIDA NIH HHS; R21 AA014396/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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