Document Detail


Acute pesticides poisonings in pregnant women.
MedLine Citation:
PMID:  9478098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
44 pregnant women were treated at the Department of Clinical Toxicology in years 1986-1996 as a result of acute poisonings with different xenobiotics. Acute pesticide poisoning that involved 4 cases were always severe and had dramatic clinical course. Carbofuran intoxication stated in a 17-year-old woman (18 weeks of pregnancy) resulted in fetus death. Toxicological findings revealed that the level of the poison in the mothers blood was comparable to that in the fetus. Carbofuran evidently passed the placental barrier in concentration which was sufficient to cause the fetus death. In the second woman (20-year-old, 12 weeks pregnant) who was classified as severely poisoned on admission to the clinic a spontaneous abortion was stated on 27th day after poisoning. The highest level of carbofuran in the blood of the mother was 9.71 micrograms/g. A 30-year-old woman, 10 weeks pregnant took formothion (50 ml) per vaginam in order to provoke abortion. She was classified as moderately poisoned. Gynecological examination and ultrasonography confirmed the pregnancy. The fetus heart tones were audible. The patient was discharged from hospital after 3 days at her own request in a good general condition. The concentration of formothion in washings from vagina was similar to the levels observed in blood serum on the patient admission to the Clinic, and 24 hour later. A 21-year-old woman, 5 month pregnant ingested an unknown amount of endosulfan to provoke abortion. Gynecological examination and abdominal ultrasonography revealed longitudinal pelvic presentation of fetus. Neither fetal movement nor heart tones were audible as early as four hours after the clinical symptoms occurred. Such low concentration of endosulfan in the blood of the mother as 0.47 microgram/g of the poison caused relatively quick fetus death. The highest levels of endosulfan were found in the liver and in the fetus kidneys.
Authors:
K Sancewicz-Pach; B Groszek; D Pach; M Kłys
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Przegla̧d lekarski     Volume:  54     ISSN:  0033-2240     ISO Abbreviation:  Prz. Lek.     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  19840720R     Medline TA:  Przegl Lek     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  741-4     Citation Subset:  IM    
Affiliation:
Department of Pediatric Nephrology, Polish-American Children Hospital, Collegium Medicum, Jagiellonian University, Kraków.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Adolescent
Adult
Brain Chemistry
Carbofuran / analysis,  poisoning*
Endosulfan / analysis,  poisoning*
Female
Fetal Death / chemically induced*
Fetus / chemistry,  drug effects
Humans
Insecticides / analysis,  poisoning*
Kidney / chemistry
Liver / chemistry
Maternal-Fetal Exchange
Organothiophosphorus Compounds / analysis,  poisoning*
Pregnancy
Ultrasonography, Prenatal
Xenobiotics / analysis,  poisoning
Chemical
Reg. No./Substance:
0/Insecticides; 0/Organothiophosphorus Compounds; 0/Xenobiotics; 115-29-7/Endosulfan; 1563-66-2/Carbofuran; 2540-82-1/formothion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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