Document Detail


Acute pancreatitis in pediatric- and adult-onset systemic lupus erythematosus: a comparison and review of the literature.
MedLine Citation:
PMID:  21335396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study aimed to compare differences of acute pancreatitis between adult- and pediatric-onset systemic lupus erythematosus (SLE) patients and to clarify the risk factors for mortality. Medical records that carried the dual diagnosis of SLE and acute pancreatitis between 1991 and 2005 were reviewed. Forty-eight episodes of acute pancreatitis were identified in 13 pediatric-onset SLE (pSLE) and 27 adult-onset SLE (aSLE) patients. The prevalence was 1.34% overall, with higher prevalence in pSLE (5.22%) compared with aSLE (0.99%) (p < 0.001). The SLEDAI score on presentation of acute pancreatitis was higher in pSLE (mean ± SD: 21.77 ± 13.09) than in aSLE patients (13.37 ± 8.32) (p = 0.05). Eleven patients died during episodes of acute pancreatitis and mortality rate was significantly higher in pSLE than in the aSLE group (53.8% and 14.8%, respectively, p = 0.015). Mortality was associated with concurrent SLE symptoms (p = 0.049), higher SLEDAI score at presentation of acute pancreatitis (p = 0.011), severe acute pancreatitis (p < 0.001), and the presence of complications (p < 0.001). The multivariate logistic regression analysis showed that severity of acute pancreatitis was the most powerful risk factor for mortality in SLE patients with this disease. In summary, our results indicate that acute pancreatitis occurs more frequently, tends to be more severe, and is associated with higher mortality in pSLE patients when compared with aSLE patient.
Authors:
Ch Wang; Tc Yao; Yl Huang; Ls Ou; Kw Yeh; Jl Huang
Related Documents :
20414466 - Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based ...
6410766 - Morphologic cerebral changes in patients undergoing dialysis for renal failure.
598056 - Folic acid status of patients with chronic renal failure maintained by dialysis.
17897106 - Nephrogenic systemic fibrosis: a nephrologist's perspective.
24672666 - A patient with eosinophilic gastroenteritis presenting with acute pancreatitis and asci...
10995526 - Circadian rhythm of blood pressure in renal disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-18
Journal Detail:
Title:  Lupus     Volume:  -     ISSN:  1477-0962     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Allergy, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Deletion or overexpression of mitochondrial NAD+ carriers in Saccharomyces cerevisiae alters cellula...
Next Document:  Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with n...