Document Detail

Acute pancreatitis following doxycycline and ornidazole coadministration.
MedLine Citation:
PMID:  21068497     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Drugs are related to the etiology of acute pancreatitis in approximately 1.4-2.0% of cases. Although antibiotics constitute a small number of the drugs suspected, tetracycline is the most encountered antibiotic among those drugs.
CASE REPORT: A 33-year-old woman was admitted to the emergency room complaining of nausea and abdominal pain after the use of doxycycline 500 mg and ornidazole 500 mg twice daily for three days for a vaginal infection. She experienced epigastric pain, which worsened over time and radiated to her back. After a detailed evaluation, she was diagnosed as having mild acute pancreatitis which improved with medical treatment. All other possible causes of pancreatitis were eliminated.
CONCLUSIONS: Antibiotic-associated pancreatitis usually has a silent and mild course. To the best of our knowledge the literature reports only two cases of doxycycline-induced acute pancreatitis reported and there are no reports of pancreatitis associated with ornidazole. Our case is the first case reported in which doxycycline and ornidazole coadministration induced acute pancreatitis.
Serkan Ocal; Haldun Selçuk; Murat Korkmaz; Hakan Unal; Uğur Yilmaz
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-11-09
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  11     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  614-6     Citation Subset:  IM    
Department of Gastroenterology, Baskent University, Ankara, Turkey.
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MeSH Terms
Acute Disease
Anti-Bacterial Agents / administration & dosage,  adverse effects
Doxycycline / administration & dosage*,  adverse effects*
Drug Administration Schedule
Drug Therapy, Combination / adverse effects
Ornidazole / administration & dosage*,  adverse effects*
Pancreatitis / chemically induced*,  diagnosis
Vaginal Diseases / drug therapy
Reg. No./Substance:
0/Anti-Bacterial Agents; 16773-42-5/Ornidazole; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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