Document Detail

Acute pancreatitis due to pravastatin therapy.
MedLine Citation:
PMID:  12743419     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Few data exist about the incidence of drug-induced pancreatitis in the general population. Drugs are related to the etiology of pancreatitis in about 1.4-2% of cases. Statins are generally well tolerated. Acute pancreatitis has been reported in a few cases treated with atorvastatin, fluvastatin, lovastatin and simvastatin. CASE REPORT: We report the case of a 56-year-old patient who, after 6 months of treatment with pravastatin 20 mg once daily for hypercholesterolemia, presented with acute pancreatitis. Other causes of the disease were ruled out. Five months later, the patient, on his own initiative, reintroduced pravastatin and acute pancreatitis recurred after 3 days. CONCLUSION: To our knowledge this is the first report of pravastatin-induced pancreatitis and further strengthens the fact that statins may cause acute pancreatitis.
George K Anagnostopoulos; Stavros Tsiakos; George Margantinis; Panagiotis Kostopoulos; Dimitrios Arvanitidis
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  4     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-05-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Gastroenterology Department, 251 Hellenic Air Force and Veterans General Hospital, Athens, Greece.
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MeSH Terms
Acute Disease
Anticholesteremic Agents / adverse effects*,  therapeutic use
Hypercholesterolemia / drug therapy
Middle Aged
Pancreatitis / chemically induced*
Pravastatin / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Anticholesteremic Agents; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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