| Acute pancreatitis as a rare initial manifestation of Wegener's granulomatosis. A case based review of literature. | |
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MedLine Citation:
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PMID: 21386646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Vasculitis is a known cause of pancreatitis and other gastrointestinal symptoms; however, most of these patients have medium vessel vasculitis like polyarteritis nodosa and often there are other associated conditions like hepatitis B or clinical manifestations that suggest the diagnosis. Wegener's granulomatosis is predominantly a reno-pulmonary disorder, rarely having gastrointestinal manifestations. CASE REPORT: We report a case of Wegener's granulomatosis initially presenting as acute pancreatitis and then rapidly progressing to severe multi-organ involvement over the next few months. DISCUSSION: Pancreatic association as an initial presentation of Wegener's granulomatosis is limited to only a few reports. This extremely rare initial presentation makes the diagnostic process challenging. Two different pancreatic manifestations have been reported: as a pancreatic mass mimicking a tumor or as acute pancreatitis. The patients who presented as pancreatic head masses underwent extensive surgical procedures before the diagnosis was established. Acute pancreatitis as the initial presentation is usually associated with an aggressive course of the vasculitis and often results in a fatal outcome. CONCLUSIONS: This case illustrates Wegener's granulomatosis as a rare cause of acute pancreatitis. It emphasizes the need for thorough continued systemic clinical evaluation of patients when the etiology is not readily evident. Also, since most patients with pancreatitis due to Wegener's granulomatosis rapidly progress to severe multiorgan involvement, knowledge of a broad differential of potential etiologies and a low index of suspicion is required for timely diagnosis and treatment. |
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Authors:
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Saurabh Chawla; Mary Jo Atten; Bashar M Attar |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2011-03-09 |
Journal Detail:
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Title: JOP : Journal of the pancreas Volume: 12 ISSN: 1590-8577 ISO Abbreviation: JOP Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-09 Completed Date: 2011-08-09 Revised Date: 2011-10-18 |
Medline Journal Info:
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Nlm Unique ID: 101091810 Medline TA: JOP Country: Italy |
Other Details:
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Languages: eng Pagination: 167-9 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, John H. Stroger Hospital of Cook County and Rush University Medical School. Chicago, IL, USA. chawlasaurabh@yahoo.co.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Female Humans Middle Aged Pancreatitis / etiology*, pathology Wegener Granulomatosis / complications* |
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