Document Detail

Acute pancreatic injury in asymptomatic individuals after heavy drinking over the long-term.
MedLine Citation:
PMID:  7531668     Owner:  NLM     Status:  MEDLINE    
Recently, high-dose short-term alcohol exposure has been observed not to induce acute pancreatic damage, as evaluated by serum pancreatic enzyme activities. In this study the effect of high-dose, long-term alcohol exposure on the pancreas was investigated in 32 consecutive alcoholics admitted to a unit to treat the problems of withdrawal after a long period of heavy drinking. None of the alcoholics complained of abdominal symptoms. The signs of clinical acute pancreatitis (pain, increased serum C-reactive protein concentration or blood white cell count) were not observed in any of the alcoholics. A significant increase in serum total amylase, pancreatic isoamylase and lipase activities developed by the second day after termination of alcohol intake. These enzyme activities remained significantly increased for one week after cessation of drinking. Seven alcoholics had signs of chronic pancreatitis at ultrasonography (pancreatic calcification, pseudocyst). These results suggest that heavy alcohol intake over the long term may frequently induce subclinical pancreatic injury.
M Jaakkola; T Frey; P Sillanaukee; T Koivula; I Nordback
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  41     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-13     Completed Date:  1995-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Department of Surgery, Tampere University Hospital, Finland.
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MeSH Terms
Acute Disease
Alcoholism / complications*
Amylases / blood
Chronic Disease
Ethanol / adverse effects*
Follow-Up Studies
Isoamylase / blood
Lipase / blood
Middle Aged
Pancreatitis / blood,  chemically induced*
Phospholipases A / blood
Prospective Studies
Substance Withdrawal Syndrome*
Time Factors
Reg. No./Substance:
64-17-5/Ethanol; EC 3.1.1.-/Phospholipases A; EC; EC 3.2.1.-/Amylases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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