Document Detail

Acute pancreatic injury in asymptomatic individuals after heavy drinking over the long-term.
MedLine Citation:
PMID:  7531668     Owner:  NLM     Status:  MEDLINE    
Recently, high-dose short-term alcohol exposure has been observed not to induce acute pancreatic damage, as evaluated by serum pancreatic enzyme activities. In this study the effect of high-dose, long-term alcohol exposure on the pancreas was investigated in 32 consecutive alcoholics admitted to a unit to treat the problems of withdrawal after a long period of heavy drinking. None of the alcoholics complained of abdominal symptoms. The signs of clinical acute pancreatitis (pain, increased serum C-reactive protein concentration or blood white cell count) were not observed in any of the alcoholics. A significant increase in serum total amylase, pancreatic isoamylase and lipase activities developed by the second day after termination of alcohol intake. These enzyme activities remained significantly increased for one week after cessation of drinking. Seven alcoholics had signs of chronic pancreatitis at ultrasonography (pancreatic calcification, pseudocyst). These results suggest that heavy alcohol intake over the long term may frequently induce subclinical pancreatic injury.
M Jaakkola; T Frey; P Sillanaukee; T Koivula; I Nordback
Related Documents :
8354798 - Benefits of cardiac rehabilitation and exercise training in secondary coronary preventi...
11892678 - Correlations among selected pork quality traits.
2387948 - Leisure time exercise and lipid and lipoprotein levels in an older population.
18981938 - Aerobic exercise and postprandial lipemia in men with the metabolic syndrome.
17186298 - Plasma ghrelin responses to acute sculling exercises in elite male rowers.
22429118 - Attitudes and expectations regarding exercise in the hospital of hospitalized older adu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  41     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-13     Completed Date:  1995-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  477-82     Citation Subset:  IM    
Department of Surgery, Tampere University Hospital, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Alcoholism / complications*
Amylases / blood
Chronic Disease
Ethanol / adverse effects*
Follow-Up Studies
Isoamylase / blood
Lipase / blood
Middle Aged
Pancreatitis / blood,  chemically induced*
Phospholipases A / blood
Prospective Studies
Substance Withdrawal Syndrome*
Time Factors
Reg. No./Substance:
64-17-5/Ethanol; EC 3.1.1.-/Phospholipases A; EC; EC 3.2.1.-/Amylases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence of HBV and HCV infection in Japanese patients with hepatocellular carcinoma.
Next Document:  Transgenic mouse model of hemifacial microsomia: cloning and characterization of insertional mutatio...