| Acute ozone exposure increases plasma prostaglandin F2 alpha in ozone-sensitive human subjects. | |
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MedLine Citation:
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PMID: 2751167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty O3-sensitive and 2O O3-nonsensitive subjects participated in a study to investigate the effects of disparate O3 sensitivity on plasma prostaglandin F2 alpha) responses consequent to exposure to ambient O3 concentrations. Subjects were selected from a pool of 75 normal healthy college-aged males who had been previously exposed to 0.35 ppm O3 for 1 h at an exercising VE of 60 L/min. The selection criterion used was the observed decrement in FEV1 after the O3 exposure: O3-sensitive, FEV1 decrement greater than 24%; O3-nonsensitive, FEV1 decrement less than 11%. Each subject was exposed to filtered air and to 0.20 and 0.35 ppm O3 for 80 min while exercising at a VE of 50 L/min. These experimental protocols were divided into two 40-min sessions separated by a period of 4 to 10 min. PGF2 alpha, FVC, FEV1, and FEF25-75 were evaluated before, during, and after each protocol. SGaw and Vtg were measured before and after each protocol. Plasma PGF2 alpha was significantly increased in the O3-sensitive group during and after the 0.35-ppm O3 exposure. |
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Authors:
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E S Schelegle; W C Adams; S N Giri; A D Siefkin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American review of respiratory disease Volume: 140 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-11 Completed Date: 1989-08-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 211-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Physical Education, University of California, Davis 95616. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dinoprost / blood* Exercise Forced Expiratory Volume Humans Male Ozone / adverse effects* Vital Capacity |
| Grant Support | |
ID/Acronym/Agency:
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HL 07013-14/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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