| Acute oxygen-ozone administration to rats protects the heart from ischemia reperfusion infarct. | |
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MedLine Citation:
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PMID: 18827966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE AND DESIGN: We tested here the effects of acute administration of an oxygen/ozone (O3) mixture on the myocardial tissue damage following an ischemic event.MATERIAL OR SUBJECTS: The study was done in Sprague-Dawley rats subjected to acute myocardial ischemia/reperfusion (I/R). TREATMENT: 100; 150; and 300 microg/kg oxygen/O3 mixture were insufflated intraperitoneally 1 h prior to I/R. METHODS: Myocardial infarct size measurement and immunhistochemistry or ELISA for nitrotyrosine, CD68, CD8,CD4 and caspase-3 were done. RESULTS: I/R produced a marked damage in the rat left ventricle with an infarct size as percentage of the area at risk (IS/ AR) of approximately 45 +/- 4% . Rats insufflated with a oxygen/O3 mixture showed a significant 2-h cardio-protection (e. g. infarct size over area at risk for the dose of 300 microg/kg was approximately 30 +/- 3%,) as compared with control rats (P <0.01). This effect was paralleled by a decrease in tissue levels of immunostaining for biomarkers of nitrosative stress (nitrotyrosine), inflammation (CD68) and immunity response (CD8 and CD4) between heart tissues from infarcted rats and infarcted O3 treated rats. CONCLUSIONS: These data indicate that the tissue and biochemical damages associated with myocardial ischemia/reperfusion can be counteracted by an acute O3 pretreatment. |
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Authors:
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C Di Filippo; R Marfella; P Capodanno; F Ferraraccio; L Coppola; M Luongo; L Mascolo; C Luongo; A Capuano; F Rossi; M D'Amico |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 57 ISSN: 1023-3830 ISO Abbreviation: Inflamm. Res. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-12-25 Completed Date: 2009-03-04 Revised Date: 2010-03-23 |
Medline Journal Info:
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Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 445-9 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / drug effects* Humans Male Myocardial Infarction / drug therapy, pathology, prevention & control* Myocardial Ischemia / drug therapy* Myocardial Reperfusion Injury / prevention & control* Oxygen* / pharmacology, therapeutic use Ozone* / pharmacology, therapeutic use Random Allocation Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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