| Acute neurohumoral response to electroconvulsive therapy during pregnancy. A case report. | |
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MedLine Citation:
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PMID: 2573726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neurohumoral changes induced by electroconvulsive therapy (ECT) in pregnancy have not been described previously. In the nonpregnant adult, ECT causes an acute rise in prolactin, adrenocorticotropic hormone (ACTH), cortisol, norepinephrine, epinephrine and beta-endorphin. Because pregnancy alters the production and release of these hormones, consideration should be given to how ECT may further alter the neuroendocrine response, with possible implications for the success of treatment and the fetal response. A 30-year-old woman with a major affective disorder underwent a course of ECT beginning at 23 weeks' gestation. Serial hormonal assays of peripheral venous samples from -30 to +240 minutes were obtained during her first treatment. The prolactin, ACTH, norepinephrine, epinephrine, beta-endorphin, dopamine and oxytocin levels rose acutely and returned to baseline during observation. The maternal vital signs were stable. No increase in uterine activity or fetal heart rate abnormalities were observed during any treatment. A healthy infant weighing 2,900 g was delivered at term, with Apgar scores of 9 and 9 and no problems. We conclude that there are acute neurohumoral changes in specific hormones with ECT in pregnancy, but none of these changes appeared to adversely affect the fetus in our case. |
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Authors:
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E J Griffiths; R P Lorenz; S Baxter; N S Talon |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 34 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-01-08 Completed Date: 1990-01-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 907-11 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, William Beaumont Hospital, Royal Oak, MI 48072. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affective Disorders, Psychotic / blood, therapy* Electroconvulsive Therapy* Female Humans Hydrocortisone / blood Neurotransmitter Agents / blood Pregnancy Pregnancy Complications / blood, therapy* Prolactin / blood |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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