Document Detail

Acute negative intracranial pressure effects on the auditory evoked response in rabbits.
MedLine Citation:
PMID:  4080119     Owner:  NLM     Status:  MEDLINE    
Recent clinical experience has shown that significant neurological symptoms and deficits occur in patients who have been shunted for hydrocephalus when "overshunting" produces unusual negative intracranial pressure (ICP). Therefore, the effect of acute negative ICP .on the early auditory evoked response (AER) was studied in the normal New Zealand rabbit. ICP was reduced to -50, -100, and -150 mm H2O below base line pressure. The AER after rarefaction auditory stimulation was obtained from ongoing electroencephalographic activity at the base line ICP and at each of the three negative ICP levels. Off-line statistical evaluation of the AER showed minimal changes in the absolute and interpeak latencies of N-0 to P-5 at some negative pressures. However, no statistically significant changes were observed for any of the measures for grouped data. At the negative ICP levels studied, the cerebrospinal fluid (CSF) pulse pressure was considerably augmented over base line measures. Such augmentation of the CSF pulse pressure may be the cause of the minimal effects observed on the AER, which may be due to a neuropraxic effect rather than ischemia from cerebral perfusion pressure changes.
J P Blanks; D McPherson; E L Foltz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurosurgery     Volume:  17     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-19     Completed Date:  1986-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-82     Citation Subset:  IM    
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MeSH Terms
Auditory Pathways / physiology
Blood Pressure
Brain / physiology*
Evoked Potentials, Auditory*
Intracranial Pressure*
Neural Conduction
Reaction Time / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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