| Acute myopathy in severe acute asthma treated with intravenously administered corticosteroids. | |
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MedLine Citation:
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PMID: 3341634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An association between the use of parenteral corticosteroids in acute asthma and the development of an acute myopathy was first reported in 1977. We report 2 further cases that contribute significantly to our knowledge of this rare complication of the treatment of acute asthma. These cases demonstrate that the acute myopathy is not just a complication of the use of parenteral hydrocortisone in patients requiring ventilatory support during an episode of acute asthma. The acute myopathy can occur with several parenteral corticosteroids, may be severe (with rhabdomyolysis and myoglobinuria), and may have protracted morbidity. Prospective follow-up allowed demonstration of histopathology, electrophysiology, and also the contribution of various pharmacologic agents. Careful analysis of the evidence strongly implicates corticosteroids as the causative agent. |
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Authors:
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T J Williams; R E O'Hehir; D Czarny; M Horne; G Bowes |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American review of respiratory disease Volume: 137 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-14 Completed Date: 1988-03-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 460-3 Citation Subset: AIM; IM |
Affiliation:
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Respiratory Service, Alfred Hospital, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adrenal Cortex Hormones / administration & dosage, adverse effects* Adult Asthma / complications*, drug therapy, pathology Biopsy Female Humans Male Muscles / pathology Muscular Diseases / chemically induced*, pathology Necrosis Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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