Document Detail

Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic resonance in its diagnosis.
MedLine Citation:
PMID:  21106555     Owner:  NLM     Status:  In-Data-Review    
Background In patients presenting with acute cardiac symptoms, abnormal ECG and raised troponin, myocarditis may be suspected after normal angiography. Aims To analyse cardiac magnetic resonance (CMR) findings in patients with a provisional diagnosis of acute coronary syndrome (ACS) in whom acute myocarditis was subsequently considered more likely. Methods and results 79 patients referred for CMR following an admission with presumed ACS and raised serum troponin in whom no culprit lesion was detected were studied. 13% had unrecognised myocardial infarction and 6% takotsubo cardiomyopathy. The remainder (81%) were diagnosed with myocarditis. Mean age was 45±15&emsp14;years and 70% were male. Left ventricular ejection fraction (EF) was 58±10%; myocardial oedema was detected in 58%. A myocarditic pattern of late gadolinium enhancement (LGE) was detected in 92%. Abnormalities were detected more frequently in scans performed within 2&emsp14;weeks of symptom onset: oedema in 81% vs 11% (p<0.0005), and LGE in 100% vs 76% (p<0.005). In 20 patients with both an acute (<2&emsp14;weeks) and convalescent scan (>3&emsp14;weeks), oedema decreased from 84% to 39% (p<0.01) and LGE from 5.6 to 3.0 segments (p=0.005). Three patients presented with sustained ventricular tachycardia, another died suddenly 4&emsp14;days after admission and one resuscitated 7&emsp14;weeks following presentation. All 5 patients had preserved EF. Conclusions Our study emphasises the importance of access to CMR for heart attack centres. If myocarditis is suspected, CMR scanning should be performed within 14&emsp14;days. Myocarditis should not be regarded as benign, even when EF is preserved.
Pierre A Monney; Neha Sekhri; Thomas Burchell; Charles Knight; Ceri Davies; Andrew Deaner; Michael Sheaf; Suhail Baithun; Steffen Petersen; Andrew Wragg; Ajay Jain; Mark Westwood; Peter Mills; Anthony Mathur; Saidi A Mohiddin
Related Documents :
22408025 - Transcription factor chf1/hey2 regulates ec coupling and heart failure in mice through ...
2940685 - Myocarditis in mixed connective tissue disease: clinical and pathologic study of three ...
7260965 - Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis...
23897095 - Circulating micrornas as novel biomarkers for the early diagnosis of acute coronary syn...
15710285 - Cardiac remodeling and failure: from molecules to man (part i).
19670305 - Impact of intravascular ultrasound guidance in patients with acute myocardial infarctio...
Publication Detail:
Type:  Journal Article     Date:  2010-11-23
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1312-8     Citation Subset:  AIM; IM    
The Heart Muscle Disease Clinic, London Chest Hospital, Barts and The London NHS Trust, Bonner Road, London E2 9JX, UK;
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response.
Next Document:  Controversies in the cardiovascular management of type 2 diabetes.