Document Detail

Acute myocardiotoxicity during 5-fluorouracil therapy.
MedLine Citation:
PMID:  2351781     Owner:  NLM     Status:  MEDLINE    
A 38-year-old man with a colonic carcinoma experienced cardiogenic shock during continuous intravenous treatment with 5-fluorouracil (5-FU), without clinical or electrical signs of coronary insufficiency and with a normal coronary angiogram. His symptoms resolved after eight days of inotropic and vasodilator therapy. Because of the severity of the shock, rechallenge was not performed. This is the first case of acute cardiac failure without coronary ischemia, associated with 5-FU monotherapy. Experimental studies suggest that this adverse effect could be due to myocardial accumulation of 5-FU leading to depletion of high energy phosphate compounds. This might also explain the more frequently seen acute coronary insufficiency due to 5-FU.
B Misset; B Escudier; B Leclercq; D Rivara; P Rougier; G Nitenberg
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  16     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-13     Completed Date:  1990-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  210-1     Citation Subset:  IM    
Service de Réanimation Médico-Chirurgicale, Institut G. Roussy, Villejuif, France.
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MeSH Terms
Cardiomyopathies / chemically induced*,  complications,  diagnosis
Colonic Neoplasms / drug therapy*
Fluorouracil / administration & dosage,  adverse effects*,  therapeutic use
Infusions, Intravenous
Shock, Cardiogenic / etiology*,  physiopathology
Reg. No./Substance:

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