Document Detail


Acute myocardial ischemia: magnetic resonance contrast enhancement with gadolinium-DTPA.
MedLine Citation:
PMID:  6473777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gadolinium-DTPA (Gd-DTPA) was used to improve the diagnostic utility of magnetic resonance (MR) in detecting early ischemia, before the onset of infarction. Following one minute of left anterior descending coronary artery occlusion, 9 dogs were intravenously injected with either 0.5 mM/kg of Gd-DTPA (6 dogs) or normal saline (3 dogs). One more minute was allowed for perfusion of injectate prior to cardiectomy and MR imaging of the ex situ heart. There was no visible difference in intensity or alterations in magnetic relaxation times between normal and ischemic myocardium in the control (saline-injected) animals. The Gd-DTPA-injected dogs had a well-defined segment of high intensity representing the ischemic myocardium in the anterior wall of the left ventricle, due to significant T2 relaxation rate enhancement in the adjacent normal myocardium. Both T1 and T2 were significantly (p less than 0.01) shortened in the normal myocardium of the Gd-DTPA animals, but relatively greater T2 relaxation rate enhancement resulted in reduced intensity of normal myocardium, thus increasing contrast with ischemic myocardium. As a result of the significant shortening of T1 and T2 in the normal myocardium relative to the ischemic myocardium, improved delineation of the ischemic segment could be obtained using calculated T1 and T2 images. It is concluded that Gd-DTPA has the potential to expand the sensitivity and diagnostic utility of MR in the study of occlusive coronary artery disease.
Authors:
M T McNamara; C B Higgins; R L Ehman; D Revel; R Sievers; R C Brasch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  153     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1984-10-12     Completed Date:  1984-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Disease / diagnosis*,  radionuclide imaging
Dogs
Gadolinium / diagnostic use*
Magnetic Resonance Spectroscopy*
Myocardial Contraction
Myocardial Infarction / diagnosis*,  radionuclide imaging
Pentetic Acid / diagnostic use*
Grant Support
ID/Acronym/Agency:
AM 31937/AM/NIADDK NIH HHS; R01 HL 32283-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
67-43-6/Pentetic Acid; 7440-54-2/Gadolinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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