Document Detail

Acute myocardial ischemia in a patient with heterozygous alpha-2-plasmin inhibitor deficiency.
MedLine Citation:
PMID:  19593116     Owner:  NLM     Status:  MEDLINE    
In this brief report we present a patient with heterozygous alpha2 plasmin inhibitor (alpha2PI) deficiency who developed atherosclerosis and myocardial ischemia in the presence of multiple classical risk factors. Management was complicated by fear of bleeding complications with the use of antiplatelet agents and serious comorbidity.The role of alpha2PI in atherosclerosis and pathological clot formation is still not clear. This case shows, however, that atherosclerosis and acute cardiovascular events can develop in patients with reduced alpha2PI levels.
Angelique V M Brands-Nijenhuis; Peter P van Geel; Karina Meijer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  20     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  599-600     Citation Subset:  IM    
Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 97013 GZ Groningen, The Netherlands.
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MeSH Terms
Atherosclerosis / etiology,  genetics
Disease Management
Middle Aged
Myocardial Ischemia / etiology,  genetics*
Risk Factors
alpha-2-Antiplasmin / deficiency*,  genetics
Reg. No./Substance:

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