Document Detail

Acute myocardial infarction in a patient with post-splenectomy thrombocytosis: a case report and review of literature.
MedLine Citation:
PMID:  20104461     Owner:  NLM     Status:  MEDLINE    
Unlike essential thrombocytosis, which is associated with thrombotic and hemorrhagic complications, reactive thrombocytosis (RT) is usually considered a benign process without thrombotic complications. We describe a case of acute myocardial infarction in a young heavy smoker with RT following splenectomy. Coronary angiography showed a linear filling defect at mid-part of left anterior descending artery. We performed balloon angioplasty and stenting for this lesion. Aspirin and clopidogrel were administered. His in-hospital course was uneventful and platelet count returned to the normal range at four month follow-up. We concluded that RT may not be an entirely benign process, especially in patients with a history of smoking. Regular monitoring of platelet count, and possibly antithrombotic agents like aspirin prescription for high risk patients with moderate thrombocytosis, may be useful.
Samad Ghaffari; Leili Pourafkari
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Cardiovascular Research Department of Tabriz University of Medical Sciences, Madani Heart Center, Tabriz, Iran.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Aspirin / therapeutic use
Follow-Up Studies
Myocardial Infarction / etiology*,  radiography,  therapy*
Platelet Aggregation Inhibitors / therapeutic use*
Platelet Count
Splenectomy / adverse effects*
Thrombocytosis / blood,  etiology*
Ticlopidine / analogs & derivatives,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel

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