Document Detail

Acute myocardial infarction in a patient with essential thrombocythemia: successful treatment with percutaneous transluminal coronary recanalization.
MedLine Citation:
PMID:  16041176     Owner:  NLM     Status:  MEDLINE    
A 65-year-old woman with essential thrombocythemia (ET) was admitted to hospital where she was diagnosed as acute myocardial infarction (AMI). Because of abundant thrombus of right coronary arteries, percutaneous transluminal coronary recanalization by administration of urokinase was selected as the reperfusion therapy, resulting in successful revascularization with Thrombolysis in Myocardial Infarction grade III coronary flow. The maximum creatine kinase reached 507 IU/L, and left ventriculography performed at 1 month after initiation of both anticoagulant and antiplatelet therapies revealed reduced motion in the inferior wall with an ejection fraction of 57%. Despite good recovery of left ventricular function, bleeding complications, such as epistaxis or ecchymoma, which did not require blood transfusion, occurred during the clinical course. Because ET causes not only thrombus formation but also bleeding tendency, it is very important to carefully follow-up any clotting abnormality in AMI patients with ET.
Einosuke Mizuta; Shin-ichi Takeda; Norihito Sasaki; Junichiro Miake; Toshiriro Hamada; Masaki Shimoyama; Fumihito Tajima; Osamu Igawa; Chiaki Shigemasa; Ichiro Hisatome
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  69     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-09-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1000-2     Citation Subset:  IM    
Department of Regenerative Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori Graduate School of Medical Science, Tottori University, Tottori, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Myocardial Infarction / complications,  physiopathology,  therapy*
Plasminogen Activators / administration & dosage*
Thrombocythemia, Essential / complications,  drug therapy*,  physiopathology
Urokinase-Type Plasminogen Activator / administration & dosage*
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators; EC Plasminogen Activator

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