Document Detail

Acute myocardial infarction following oral methyl-ergometrine intake.
MedLine Citation:
PMID:  19219407     Owner:  NLM     Status:  MEDLINE    
Ergot derivatives are frequently administrated during cesarean delivery, induced abortion, or post-partum hemorrhage to promote uterine contractions. Ergot derivatives may also induce coronary spasm and intravenous ergonovine is used in cardiac catheterization laboratories as a diagnostic agent. Serious ischemic cardiac events related to ergonovine are rare and have most often been described after intravenous use. We report the case of a 38-year-old woman with a ST elevation myocardial infarction (STEMI) few days after artificially induced abortion by oral prescription of methylergometrine. Coronary angiography performed 2 days after onset of chest pain did not reveal any abnormalities of the coronary arteries but a provocative test using intravenous methylergometrine was positive with reproduction of chest pain, ECG changes and with a significant narrowing localized on the second segment of the left anterior descending artery at the angiogram. Thus, since methylergometrin may clearly induce coronary spasm when prescribed orally, chest pain occurring under oral treatment should require immediate attention even if atypical or in the absence of cardiovascular risk factors.
Axel de Labriolle; Olivier Genée; Laurens Mitchell Heggs; Laurent Fauchier
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-02-14
Journal Detail:
Title:  Cardiovascular toxicology     Volume:  9     ISSN:  1559-0259     ISO Abbreviation:  Cardiovasc. Toxicol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-10     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135818     Medline TA:  Cardiovasc Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-8     Citation Subset:  IM    
Service de Cardiologie, Pôle Coeur Thorax Vasculaire Hémostase, Centre Hospitalier Universitaire Trousseau, 37044, Tours, France.
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MeSH Terms
Abortifacient Agents / administration & dosage,  adverse effects*
Administration, Oral
Angina Pectoris / chemically induced
Coronary Angiography
Coronary Vasospasm / chemically induced*,  diagnosis,  drug therapy
Drug Therapy, Combination
Methylergonovine / administration & dosage,  adverse effects*
Myocardial Infarction / chemically induced*,  diagnosis,  drug therapy
Oxytocics / administration & dosage,  adverse effects*
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Abortifacient Agents; 0/Oxytocics; 0/Vasodilator Agents; 113-42-8/Methylergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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