Document Detail

Acute myocardial infarction attributable to adrenergic crises in a patient with pheochromocytoma and neurofibromatosis 1.
MedLine Citation:
PMID:  17599858     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a rare case of acute myocardial infarction in a patient with neurofibromatosis 1 and pheochromocytoma and to review the literature on the coexistence of these 2 diseases, the causes of myocardial injury in patients with pheochromocytoma, and the utility of genetic testing and pheochromocytoma screening for those patients and their families. METHODS: We present a case report, including the detailed clinical, laboratory, and radiographic data, results of adrenal mass pathology, and results of coronary angiography. We also survey other relevant reports available in the literature. RESULTS: A 43-year-old woman with a history of long-standing hypertension, neurofibromatosis 1, headaches, sweating, and palpitations presented to the hospital with chest pain and shortness of breath. She was found to have an acute myocardial infarction and pulmonary edema, as well as a right adrenal mass. A pheochromocytoma was suspected, and phenoxybenzamine was added to her treatment regimen. Cardiac catheterization showed nonobstructive coronary disease. The levels of plasma catecholamine metabolites were extremely high. The patient underwent uncomplicated laparoscopic right adrenalectomy 2 weeks after this admission. Surgical pathology confirmed the diagnosis of pheochromocytoma. CONCLUSION: Adrenergic crisis attributable to pheochromocytoma can result in acute myocardial infarction even in the absence of obstructive coronary disease. Inclusion of pheochromocytoma in the differential diagnosis of hypertension in patients with neurofibromatosis is very important and helps avoid mistakes in the management of such patients.
Lioubov S Boulkina; Christopher A Newton; Almond J Drake; Robert J Tanenberg
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  13     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-07-19     Revised Date:  2007-10-30    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
Department of Endocrinology, University of North Carolina at Chapel Hill, USA.
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MeSH Terms
Adrenal Gland Neoplasms / blood,  complications*,  surgery
Catecholamines / adverse effects,  blood
Myocardial Infarction / etiology*
Neurofibromatosis 1 / complications*
Pheochromocytoma / blood,  complications*,  surgery
Reg. No./Substance:

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