| Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible. | |
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MedLine Citation:
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PMID: 22964337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil (5-FU) after absorbtion. Capecitabine and its active metabolite, 5-FU, have cardiotoxic effects with reported instances of acute coronary syndromes caused due to coronary vasospasm. However, these agents exert toxic effects on cardiovascular system and beyond vasospasm provacation. We report a 46-year-old patient diagnosed as acute inferior infarction who is treated with capecitabine for 3 months due to metastatic breast carcinoma, in whom thrombotic coronary occlusion was observed in angiography. This case demonstrates that apart from vasospasm, coronary thrombosis could be observed after capecitabine treatment, with a possible direct effect of this drug. |
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Authors:
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Tolga Sinan Güvenç; Emel Celiker; Kazim Serhan Ozcan; Erkan Ilhan; Mehmet Eren |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 125 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-11 Completed Date: 2013-02-13 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 3349-51 Citation Subset: IM |
Affiliation:
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Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey. tsguvenc@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Thrombosis
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chemically induced Coronary Vasospasm / chemically induced* Deoxycytidine / adverse effects, analogs & derivatives*, therapeutic use Female Fluorouracil / adverse effects, analogs & derivatives*, therapeutic use Humans Middle Aged Myocardial Infarction / chemically induced* |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil; 6804DJ8Z9U/capecitabine; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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