Document Detail


Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.
MedLine Citation:
PMID:  17412887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.
Authors:
Luke F Peterson; Anita Boyapati; Eun-Young Ahn; Joseph R Biggs; Akiko Joo Okumura; Miao-Chia Lo; Ming Yan; Dong-Er Zhang
Related Documents :
12463597 - Acute myeloid leukemia (fab-m2) with a masked type of t(8;21) translocation revealed by...
9136917 - Tandem duplication of the mll gene in myelodysplastic syndrome-derived overt leukemia w...
11550287 - Establishment of a cell line with aml1-mtg8, tp53, and tp73 abnormalities from acute my...
17721327 - A novel variant of syt-ssx1 fusion gene in a case of spindle cell synovial sarcoma.
17429837 - Loss of heterozygosity and human telomerase reverse transcriptase (htert) expression in...
15066457 - Analysis of the daz gene family in cryptorchidism and idiopathic male infertility.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-04-05
Journal Detail:
Title:  Blood     Volume:  110     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  799-805     Citation Subset:  AIM; IM    
Affiliation:
Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transformation, Neoplastic / genetics*,  metabolism
Chromosomes, Human, Pair 21 / genetics*,  metabolism
Chromosomes, Human, Pair 8 / genetics*,  metabolism
Core Binding Factor Alpha 2 Subunit / biosynthesis,  genetics*
Humans
Leukemia, Myeloid, Acute / genetics*,  metabolism,  pathology
Mice
Oncogene Proteins, Fusion / biosynthesis,  genetics*
Transcription, Genetic
Translocation, Genetic*
Grant Support
ID/Acronym/Agency:
CA 104509/CA/NCI NIH HHS; CA 96735/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/AML1-ETO fusion protein, human; 0/Core Binding Factor Alpha 2 Subunit; 0/Oncogene Proteins, Fusion
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated ...
Next Document:  Endothelial potential of human embryonic stem cells.