Document Detail

Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.
MedLine Citation:
PMID:  17412887     Owner:  NLM     Status:  MEDLINE    
Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.
Luke F Peterson; Anita Boyapati; Eun-Young Ahn; Joseph R Biggs; Akiko Joo Okumura; Miao-Chia Lo; Ming Yan; Dong-Er Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-04-05
Journal Detail:
Title:  Blood     Volume:  110     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-09-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  799-805     Citation Subset:  AIM; IM    
Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Cell Transformation, Neoplastic / genetics*,  metabolism
Chromosomes, Human, Pair 21 / genetics*,  metabolism
Chromosomes, Human, Pair 8 / genetics*,  metabolism
Core Binding Factor Alpha 2 Subunit / biosynthesis,  genetics*
Leukemia, Myeloid, Acute / genetics*,  metabolism,  pathology
Oncogene Proteins, Fusion / biosynthesis,  genetics*
Transcription, Genetic
Translocation, Genetic*
Grant Support
Reg. No./Substance:
0/AML1-ETO fusion protein, human; 0/Core Binding Factor Alpha 2 Subunit; 0/Oncogene Proteins, Fusion

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