Document Detail

Acute myeloid leukemia induced by mitoxantrone treatment for aggressive multiple sclerosis.
MedLine Citation:
PMID:  18612769     Owner:  NLM     Status:  MEDLINE    
Acute myeloid leukemia (t-AML) is one of the worst adverse events of mitoxantrone treatment, but the exact risk in multiple sclerosis (MS) patients is not yet known. We describe a case wherein the patient developed t-AML 11 months after mitoxantrone had been discontinued. The patient was treated by polychemotherapy and autologous bone marrow transplantation with complete recovery of t-AML and stabilization of the neurological disease.
Marco Capobianco; Simona Malucchi; Stefano Ulisciani; Carmen Fava; Giovanna Rege Cambrin; Luigina Avonto; Giuseppe Saglio; Antonio Bertolotto
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-07-09
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  29     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-09     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  185-7     Citation Subset:  IM    
Centro di Riferimento Regionale Sclerosi Multipla & Neurobiologia Clinica, Aou S Luigi Gonzaga, Regione Gonzole 10, Orbassano TO, Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow Transplantation
DNA Topoisomerases, Type II / antagonists & inhibitors,  metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors / adverse effects
Immunosuppressive Agents / adverse effects*
Leukemia, Myeloid, Acute / chemically induced*,  physiopathology
Mitoxantrone / adverse effects*
Multiple Sclerosis / drug therapy*
Remission Induction
Treatment Outcome
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Immunosuppressive Agents; 65271-80-9/Mitoxantrone; EC Topoisomerases, Type II

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