| Acute myeloid leukemia induced by mitoxantrone treatment for aggressive multiple sclerosis. | |
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MedLine Citation:
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PMID: 18612769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute myeloid leukemia (t-AML) is one of the worst adverse events of mitoxantrone treatment, but the exact risk in multiple sclerosis (MS) patients is not yet known. We describe a case wherein the patient developed t-AML 11 months after mitoxantrone had been discontinued. The patient was treated by polychemotherapy and autologous bone marrow transplantation with complete recovery of t-AML and stabilization of the neurological disease. |
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Authors:
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Marco Capobianco; Simona Malucchi; Stefano Ulisciani; Carmen Fava; Giovanna Rege Cambrin; Luigina Avonto; Giuseppe Saglio; Antonio Bertolotto |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-07-09 |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 29 ISSN: 1590-1874 ISO Abbreviation: Neurol. Sci. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-09 Completed Date: 2008-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 185-7 Citation Subset: IM |
Affiliation:
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Centro di Riferimento Regionale Sclerosi Multipla & Neurobiologia Clinica, Aou S Luigi Gonzaga, Regione Gonzole 10, Orbassano TO, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Bone Marrow Transplantation DNA Topoisomerases, Type II / antagonists & inhibitors, metabolism Dose-Response Relationship, Drug Enzyme Inhibitors / adverse effects Female Humans Immunosuppressive Agents / adverse effects* Leukemia, Myeloid, Acute / chemically induced*, physiopathology Mitoxantrone / adverse effects* Multiple Sclerosis / drug therapy* Remission Induction Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Immunosuppressive Agents; 65271-80-9/Mitoxantrone; EC 5.99.1.3/DNA Topoisomerases, Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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