| Acute myeloid leukemia in a young girl presenting with mediastinal granulocytic sarcoma invading pericardium and causing superior vena cava syndrome. | |
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MedLine Citation:
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PMID: 19956024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 1-year-4-month-old girl who presented with pericardial effusion and superior vena cava (SVC) syndrome caused by a mediastinal mass was later proved to be a case of acute myeloid leukemia (AML) with mixed-lineage leukemia-gene translocation. The unusual presentation and the giant blasts with basophilic vacuolated cytoplasm had led to initial misdiagnosis of mediastinal lymphoma. She developed progressive SVC syndrome, unresolved pericardial effusion, and extensive leukemia cutis after initial induction therapy. She died soon after second-course chemotherapy. To our knowledge, this is the first reported case of childhood acute myeloid leukemia presenting with mediastinal granulocytic sarcoma causing pericardium invasion and SVC syndrome. |
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Authors:
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Ming-Horng Tsai; Chao-Ping Yang; Hung-Tao Chung; Lee-Yung Shih |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 31 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-01-07 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 980-2 Citation Subset: IM |
Affiliation:
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Division of Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use Diagnosis, Differential Fatal Outcome Female Humans Infant Leukemia, Myeloid, Acute / drug therapy, pathology* Mediastinal Neoplasms / diagnosis*, drug therapy Pericardial Effusion / etiology Pericardium / pathology* Sarcoma, Myeloid / diagnosis*, drug therapy Superior Vena Cava Syndrome / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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